Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report

Jennifer Cable¹, Jeffrey C Rathmell², Erika L Pearce^{3

4}, Ping-Chih Ho⁵, Marcia C Haigis⁶, Murad R Mamedov⁷, Meng-Ju Wu^{8

9}, Susan M Kaech¹⁰, Lydia Lynch¹¹, Mark A Febbraio¹², Sagar P Bapat¹³, Hanna S Hong¹⁴, Weiping Zou¹⁵, Yasmine Belkaid¹⁶, Zuri A Sullivan¹⁷, Andrea Keller¹⁸, Stefanie K Wculek¹⁹, Douglas R Green²⁰, Catherine Postic²¹, Ido Amit²², Salvador Aznar Benitah²³, Russell G Jones²⁴, Miguel Reina-Campos²⁵, Santiago Valle Torres²⁶, Semir Beyaz²⁷, Donal Brennan²⁸, Luke A J O'Neill²⁹, Rachel J Perry³⁰, Dirk Brenner^{31

32

33}

Affiliations

¹ PhD Science Writer, New York, New York, USA.
² Vanderbilt-Ingram Cancer Center; Vanderbilt Center for Immunobiology; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
³ Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA.
⁴ Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
⁵ Department of Fundamental Oncology and Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.
⁶ Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
⁷ Gladstone-UCSF Institute of Genomic Immunology and Department of Medicine, University of California San Francisco, San Francisco, California, USA.
⁸ Cancer Center, Massachusetts General Hospital; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
⁹ Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
¹⁰ NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, California, USA.
¹¹ Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
¹² Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
¹³ Diabetes Center and Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
¹⁴ Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.
¹⁵ Department of Surgery; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center; Department of Pathology; Graduate Program in Immunology; Graduate Program in Cancer Biology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
¹⁶ Metaorganism Immunity Section, Laboratory of Immune System Biology, and NIAID Microbiome Program National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
¹⁷ Department of Immunobiology, Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA.
¹⁸ Department of Biological Chemistry and Pharmacology, College of Medicine; and Comprehensive Cancer Center, Wexner Medical Center, Arthur G. James Cancer Hospital, The Ohio State University, Columbus, Ohio, USA.
¹⁹ Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
²⁰ St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
²¹ Université Paris Cité, CNRS, INSERM, Institut Cochin, Paris, France.
²² Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
²³ Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST) and Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
²⁴ Department of Metabolism and Nutritional Programming, Van Andel Research Institute, Grand Rapids, Michigan, USA.
²⁵ University of California, San Diego, La Jolla, California, USA.
²⁶ Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.
²⁷ Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
²⁸ UCD Gynecological Oncology Group, UCD School of Medicine, Catherine McAuley Research Centre, Mater Misericordiae University Hospital, Belfield, Ireland.
²⁹ School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.
³⁰ Department of Cellular and Molecular Physiology and Department of Internal Medicine (Endocrinology), Yale University School of Medicine, New Haven, Connecticut, USA.
³¹ Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
³² Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg.
³³ Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark.

PMID: 36960914
PMCID: PMC10367315
DOI: 10.1111/nyas.14976

Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report

Jennifer Cable et al. Ann N Y Acad Sci. 2023 May.

. 2023 May;1523(1):38-50.

doi: 10.1111/nyas.14976. Epub 2023 Mar 24.

Authors

Affiliations

¹ PhD Science Writer, New York, New York, USA.
² Vanderbilt-Ingram Cancer Center; Vanderbilt Center for Immunobiology; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
³ Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA.
⁴ Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
⁵ Department of Fundamental Oncology and Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.
⁶ Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
⁷ Gladstone-UCSF Institute of Genomic Immunology and Department of Medicine, University of California San Francisco, San Francisco, California, USA.
⁸ Cancer Center, Massachusetts General Hospital; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
⁹ Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
¹⁰ NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, California, USA.
¹¹ Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
¹² Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
¹³ Diabetes Center and Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
¹⁴ Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.
¹⁵ Department of Surgery; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center; Department of Pathology; Graduate Program in Immunology; Graduate Program in Cancer Biology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
¹⁶ Metaorganism Immunity Section, Laboratory of Immune System Biology, and NIAID Microbiome Program National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
¹⁷ Department of Immunobiology, Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA.
¹⁸ Department of Biological Chemistry and Pharmacology, College of Medicine; and Comprehensive Cancer Center, Wexner Medical Center, Arthur G. James Cancer Hospital, The Ohio State University, Columbus, Ohio, USA.
¹⁹ Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
²⁰ St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
²¹ Université Paris Cité, CNRS, INSERM, Institut Cochin, Paris, France.
²² Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
²³ Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST) and Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
²⁴ Department of Metabolism and Nutritional Programming, Van Andel Research Institute, Grand Rapids, Michigan, USA.
²⁵ University of California, San Diego, La Jolla, California, USA.
²⁶ Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.
²⁷ Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
²⁸ UCD Gynecological Oncology Group, UCD School of Medicine, Catherine McAuley Research Centre, Mater Misericordiae University Hospital, Belfield, Ireland.
²⁹ School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.
³⁰ Department of Cellular and Molecular Physiology and Department of Internal Medicine (Endocrinology), Yale University School of Medicine, New Haven, Connecticut, USA.
³¹ Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
³² Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg.
³³ Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark.

PMID: 36960914
PMCID: PMC10367315
DOI: 10.1111/nyas.14976

Abstract

Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. A more holistic approach that considers both these viewpoints is needed. On September 5-8, 2022, experts in the field of immunometabolism met for the Keystone symposium "Immunometabolism at the Crossroads of Obesity and Cancer" to present recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer. Speakers highlighted new insights on the metabolic links between tumor cells and immune cells, with a focus on leveraging unique metabolic vulnerabilities of different cell types in the tumor microenvironment as therapeutic targets and demonstrated the effects of diet, the microbiome, and obesity on immune system function and cancer pathogenesis and therapy. Finally, speakers presented new technologies to interrogate the immune system and uncover novel metabolic pathways important for immunity.

Keywords: cancer; immunity; immunometabolism; immunotherapy; metabolism; obesity.

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Conflict of interest statement

Competing Interests

Jeffrey Rathmell is a founder, scientific advisory board member, and stockholder of Sitryx Therapeutics, a scientific advisory board member and stockholder of Caribou Biosciences, a member of the scientific advisory board of Nirogy Therapeutics, has consulted for Merck, Pfizer, and Mitobridge within the past three years, and has received research support from Incyte Corp., Calithera Biosciences, and Tempest Therapeutics.

Figures

**Figure 1.**
Model of AG120 (ivosidenib).

**Figure 2.**
Metabolic adaptations of tissue-resident memory CD8⁺ T cells.

See this image and copyright information in PMC

References

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Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report

Affiliations

Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous