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Case Reports
. 2023 Sep 1;69(9):e411-e414.
doi: 10.1097/MAT.0000000000001912. Epub 2023 Mar 24.

VA-ECMO Cardiac Support During Liver Transplant: A Case Report

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Case Reports

VA-ECMO Cardiac Support During Liver Transplant: A Case Report

Antonio Siniscalchi et al. ASAIO J. .

Abstract

Extracorporeal membrane oxygenation (ECMO) is a rescue therapy for cardiovascular collapse during and after liver transplantation (LT). According to the most recent guidelines, patients with severe cardiomyopathy are excluded from LT because of high-mortality risk during surgery. Intraoperative ECMO support could give these patients the opportunity to undergo LT by reducing the risk of heart failure and reperfusion syndrome. In this case report, we present a case of veno-arterial ECMO (VA-ECMO) support started before LT surgery in a patient with severe pulmonary hypertension, mitral valve steno-insufficiency, and right heart dysfunction. The presence of severe heart disease would have contraindicated LT, but simultaneous liver cirrhosis contraindicated mitral valve surgery, leaving the patient locked in a "Catch-22" state. The best solution was to perform LT with VA-ECMO support before, during, and after the surgery to reduce cardiac load and possible heart failure. LT was performed with good hemodynamic stability and the patient was successfully weaned from ECMO a few hours after surgery. At the 6 month follow-up, normal liver and kidney functions were recorded as well as an overall improvement of heart function; the patient successfully underwent mitral valve replacement and tricuspid annuloplasty 10 months after transplant and is now in good condition.

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Conflict of interest statement

Disclosure: The authors have no conflicts of interest to report.

References

    1. Braun HJ, Pulcrano ME, Weber DJ, et al.: The utility of ECMO after liver transplantation: Experience at a high-volume transplant center and review of the literature. Transplantation. 103: 1568–1573, 2019.
    1. Deatrick KB, Mazzeffi MA, Galvagno SM, et al.: Breathing life back into the kidney: Continuous renal replacement therapy and veno-venous extracorporeal membrane oxygenation. ASAIO J. 67: 208–212, 2021.
    1. Alexander S, Teshome M, Patel H, Chan EY, Doukky R: The diagnostic and prognostic utility of risk factors defined by the AHA/ACCF on the evaluation of cardiac disease in liver transplantation candidates. BMC Cardiovasc Disord. 19: 102, 2019.
    1. Xanthopoulos A, Starling RC, Kitai T, et al.: Heart failure and liver disease. J Am Coll Cardiol HF. 7: 87–97, 2019.
    1. Fukazawa K, Gologorsky E, Manmohansingh V, et al.: Is the immediate reversal of diastolic dysfunction of cirrhotic cardiomyopathy after liver transplantation a sign of themetabolic etiology? Liver Transpl. 15: 1417–1419, 2009.

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