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. 1987 Dec;100(3):135-44.
doi: 10.1007/BF00437039.

Effect of miconazole on growth and aflatoxin production by Aspergillus parasiticus

R L Buchanan  1 , S B Jones, H G Stahl
Affiliations

Effect of miconazole on growth and aflatoxin production by Aspergillus parasiticus

R L Buchanan et al. Mycopathologia. 1987 Dec.

Abstract

At 5 microM, miconazole prevented the growth of Aspergillus parasiticus Speare in a number of media. Sensitivity to miconazole was increased approximately 10-fold in a medium containing glycerol. At sub-inhibitory concentrations, miconazole stimulated aflatoxin synthesis on media which normally support toxin formation. Miconazole inhibited respiration and altered mitochondrial ultrastructure, suggesting that miconazole inhibits growth and stimulates aflatoxin production by depressing mitochondrial activity.

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