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. 2023 Aug 4;192(8):1249-1263.
doi: 10.1093/aje/kwad071.

The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort

Emily A Knapp, Amii M Kress, Corette B Parker, Grier P Page, Kristen McArthur, Kennedy K Gachigi, Akram N Alshawabkeh, Judy L Aschner, Theresa M Bastain, Carrie V Breton, Casper G Bendixsen, Patricia A Brennan, Nicole R Bush, Claudia Buss, Carlos A Camargo Jr, Diane Catellier, José F Cordero, Lisa Croen, Dana Dabelea, Sean Deoni, Viren D'Sa, Cristiane S Duarte, Anne L Dunlop, Amy J Elliott, Shohreh F Farzan, Assiamira Ferrara, Jody M Ganiban, James E Gern, Angelo P Giardino, Nissa R Towe-Goodman, Diane R Gold, Rima Habre, Ghassan B Hamra, Tina Hartert, Julie B Herbstman, Irva Hertz-Picciotto, Alison E Hipwell, Margaret R Karagas, Catherine J Karr, Kate Keenan, Jean M Kerver, Daphne Koinis-Mitchell, Bryan Lau, Barry M Lester, Leslie D Leve, Bennett Leventhal, Kaja Z LeWinn, Johnnye Lewis, Augusto A Litonjua, Kristen Lyall, Juliette C Madan, Cindy T McEvoy, Monica McGrath, John D Meeker, Rachel L Miller, Rachel Morello-Frosch, Jenae M Neiderhiser, Thomas G O'Connor, Emily Oken, Michael O'Shea, Nigel Paneth, Christina A Porucznik, Sheela Sathyanarayana, Susan L Schantz, Eliot R Spindel, Joseph B Stanford, Annemarie Stroustrup, Susan L Teitelbaum, Leonardo Trasande, Heather Volk, Pathik D Wadhwa, Scott T Weiss, Tracey J Woodruff, Rosalind J Wright, Qi Zhao, Lisa P Jacobson, On Behalf Of Program Collaborators For Environmental Influences On Child Health Outcomes

The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort

Emily A Knapp et al. Am J Epidemiol. .

Abstract

The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of Health (NIH) in 2016 to improve children's health in the United States. The EWC harmonizes extant data and collects new data using a standardized protocol, the ECHO-Wide Cohort Data Collection Protocol (EWCP). EWCP visits occur at least once per life stage, but the frequency and timing of the visits vary across cohorts. As of March 4, 2022, the EWC cohorts contributed data from 60,553 children and consented 29,622 children for new EWCP data and biospecimen collection. The median (interquartile range) age of EWCP-enrolled children was 7.5 years (3.7-11.1). Surveys, interviews, standardized examinations, laboratory analyses, and medical record abstraction are used to obtain information in 5 main outcome areas: pre-, peri-, and postnatal outcomes; neurodevelopment; obesity; airways; and positive health. Exposures include factors at the level of place (e.g., air pollution, neighborhood socioeconomic status), family (e.g., parental mental health), and individuals (e.g., diet, genomics).

Keywords: adolescent; child; child development; child health; child well-being; cohort studies; environmental exposure; epidemiologic methods.

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Figures

Figure 1
Figure 1
Environmental Influences on Child Health Outcomes (ECHO) participants are enrolled before or during pregnancy (n = 21,357) or at or after birth (n = 8,914), United States. There are 2,488 pregnancies for which a child has not yet been enrolled in the ECHO-Wide Cohort Data Collection Protocol (EWCP). In total, 29,622 children were enrolled in the EWCP as of March 4, 2022. This figure includes participants who were enrolled in the EWCP from 2018 to March 4, 2022. Enrollment in the EWCP is ongoing.
Figure 2
Figure 2
Lessons learned from the Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, United States, 2022.
See this image and copyright information in PMC

References

    1. National Institutes of Health . Environmental Influences on Child Health Outcomes (ECHO) Program: Funding. https://www.nih.gov/echo/funding. Accessed August 9, 2022.
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    1. National Institutes of Health . Environmental Influences on Child Health Outcomes (ECHO) Program. https://www.nih.gov/research-training/environmental-influences-child-hea.... Accessed August 9, 2022.
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