Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr;47(3):151727.
doi: 10.1016/j.semperi.2023.151727. Epub 2023 Mar 12.

Stem cell derived therapies to preserve and repair the developing intestine

Fikir M Mesfin  1 , Krishna Manohar  1 , Chelsea E Hunter  1 , W Christopher Shelley  1 , John P Brokaw  1 , Jianyun Liu  1 , Minglin Ma  2 , Troy A Markel  3
Affiliations

Stem cell derived therapies to preserve and repair the developing intestine

Fikir M Mesfin et al. Semin Perinatol. 2023 Apr.

Abstract

Stem cell research and the use of stem cells in therapy have seen tremendous growth in the last two decades. Neonatal intestinal disorders such as necrotizing enterocolitis, Hirschsprung disease, and gastroschisis have high morbidity and mortality and limited treatment options with varying success rates. Stem cells have been used in several pre-clinical studies to address various neonatal disorders with promising results. Stem cell and patient population selection, timing of therapy, as well as safety and quality control are some of the challenges that must be addressed prior to the widespread clinical application of stem cells. Further research and technological advances such as the use of cell delivery technology can address these challenges and allow for continued progress towards clinical translation.

Keywords: Mesenchymal stem cells; Necrotizing enterocolitis; Neonatal intestinal disorders; Stem cell therapy.

PubMed Disclaimer

Figures

Figure 1:
Figure 1:
Stem cells are classified into five categories based on their differentiation potential: totipotent, pluripotent, multipotent, oligopotent and unipotent.
See this image and copyright information in PMC

References

    1. Kolios G, Moodley Y. Introduction to stem cells and regenerative medicine. Respiration. 2013;85(1):3–10. doi:10.1159/000345615 - DOI - PubMed
    1. Daley GQ. Stem cells and the evolving notion of cellular identity. Philos Trans R Soc Lond B Biol Sci. Oct 19 2015;370(1680):20140376. doi:10.1098/rstb.2014.0376 - DOI - PMC - PubMed
    1. Zakrzewski W, Dobrzynski M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem Cell Res Ther. Feb 26 2019;10(1):68. doi:10.1186/s13287-019-1165-5 - DOI - PMC - PubMed
    1. Drucker NA, Te Winkel JP, Shelley WC, Olson KR, Markel TA. Inhibiting hydrogen sulfide production in umbilical stem cells reduces their protective effects during experimental necrotizing enterocolitis. J Pediatr Surg. Jun 2019;54(6):1168–1173. doi:10.1016/j.jpedsurg.2019.02.037 - DOI - PMC - PubMed
    1. McCulloh CJ, Olson JK, Zhou Y, Wang Y, Besner GE. Stem cells and necrotizing enterocolitis: A direct comparison of the efficacy of multiple types of stem cells. J Pediatr Surg. Jun 2017;52(6):999–1005. doi:10.1016/j.jpedsurg.2017.03.028 - DOI - PMC - PubMed

Publication types