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. 2023 May;35(5):1139-1143.
doi: 10.1007/s40520-023-02386-y. Epub 2023 Mar 25.

Association between multidimensional prognostic index (MPI) and infections in a population of older people affected by COVID-19

Francesco Saverio Ragusa  1 , Luisa Solimando  2 , Caterina Mandalà  2 , Roberta Masnata  2 , Gregorio Ciulla  2 , Stefano Ciriminna  2 , Francesco La Blasca  2 , Pasquale Mansueto  2 , Nicola Veronese  2 , Mario Barbagallo  2 ; COMEPA study authors
Collaborators, Affiliations

Association between multidimensional prognostic index (MPI) and infections in a population of older people affected by COVID-19

Francesco Saverio Ragusa et al. Aging Clin Exp Res. 2023 May.

Abstract

Background: Only limited studies analyzed a possible relationship between frailty and infections. Our aim was to investigate the possible association between higher multidimensional prognostic index (MPI) values, a tool for evaluating multidimensional frailty, and the prevalence of infectious diseases, including antibiotics' cost and the prevalence of MDR (multidrug resistance) pathogens.

Methods: Older patients, affected by COVID-19, were enrolled in the hospital of Palermo over four months.

Results: 112 participants (mean age 77.6, 55.4% males) were included. After adjusting for potential confounders, frailer participants had a higher odds of any positivity to pathogens (prevalence: 61.5%, odds ratio = 15.56, p < 0.0001) compared to a prevalence of 8.6% in more robust, including MDR, and a higher costs in antibiotics.

Conclusions: Higher MPI values, indicating frailer subjects, were associated with a higher prevalence of infections, particularly of MDR pathogens, and a consequent increase in antibiotics' cost.

Keywords: Antibiotic; Infectious diseases; Multidimensional prognostic index; Prognosis.

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Conflict of interest statement

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Prevalence of pathogens by multidimensional prognostic index values
See this image and copyright information in PMC

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