Epithelial salivary gland tumors in pediatric patients: An international collaborative study

Gabriella Alves Quixabeira Oliveira¹, Maria Eduarda Pérez-DE-Oliveira¹, Liam Robinson², Syed Ali Khurram³, Keith Hunter⁴, Paul M Speight³, Luiz Paulo Kowalski⁵, Clóvis Antonio Lopes Pinto⁶, Raísa Sales De Sá¹, Elismauro Francisco Mendonça⁷, Sebastião Silvério Sousa-Neto⁷, Dorival de Carlucci Junior⁸, Fernanda Viviane Mariano⁹, Albina Messias de Almeida Milani Altemani⁹, Manoela Domingues Martins¹⁰, Virgílio Gonzales Zanella¹¹, Danyel Elias da Cruz Perez¹², Jean Nunes Dos Santos¹³, Mário José Romañach¹⁴, Aline Corrêa Abrahão¹⁴, Bruno Augusto Benevenuto de Andrade¹⁴, Hélder Antônio Rebelo Pontes¹⁵, Jacks Jorge Junior¹, Alan Roger Santos-Silva¹, Márcio Ajudarte Lopes¹, Willie F P Van Heerden², Pablo Agustin Vargas¹⁶

Affiliations

¹ Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas (UNICAMP), São Paulo, Brazil.
² Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
³ Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, United Kingdom.
⁴ Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, United Kingdom.
⁵ Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil; Department of Head and Neck Surgery, University of São Paulo (USP) Medical School, São Paulo, Brazil.
⁶ Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil.
⁷ Department of Stomatology (Oral Pathology), School of Dentistry, Federal University of Goiás (UFG), Goiânia, Brazil.
⁸ Department of Head and Neck Surgery, University of São Paulo (USP) Medical School, São Paulo, Brazil.
⁹ Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
¹⁰ Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
¹¹ Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Head and Neck Surgery Department, Santa Rita Hospital, Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brazil.
¹² Department of Oral Pathology, School of Dentistry, Universidade Federal de Pernambuco (UFPE), Recife, Brazil.
¹³ Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia (UFBA), Salvador, Brazil.
¹⁴ Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
¹⁵ Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará (UFPA), Belém, Brazil.
¹⁶ Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas (UNICAMP), São Paulo, Brazil; Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. Electronic address: pavargas@fop.unicamp.br.

PMID: 36965251
DOI: 10.1016/j.ijporl.2023.111519

Epithelial salivary gland tumors in pediatric patients: An international collaborative study

Gabriella Alves Quixabeira Oliveira et al. Int J Pediatr Otorhinolaryngol. 2023 May.

. 2023 May:168:111519.

doi: 10.1016/j.ijporl.2023.111519. Epub 2023 Mar 21.

Authors

Affiliations

¹ Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas (UNICAMP), São Paulo, Brazil.
² Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
³ Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, United Kingdom.
⁴ Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, United Kingdom.
⁵ Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil; Department of Head and Neck Surgery, University of São Paulo (USP) Medical School, São Paulo, Brazil.
⁶ Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil.
⁷ Department of Stomatology (Oral Pathology), School of Dentistry, Federal University of Goiás (UFG), Goiânia, Brazil.
⁸ Department of Head and Neck Surgery, University of São Paulo (USP) Medical School, São Paulo, Brazil.
⁹ Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
¹⁰ Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
¹¹ Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Head and Neck Surgery Department, Santa Rita Hospital, Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brazil.
¹² Department of Oral Pathology, School of Dentistry, Universidade Federal de Pernambuco (UFPE), Recife, Brazil.
¹³ Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia (UFBA), Salvador, Brazil.
¹⁴ Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
¹⁵ Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará (UFPA), Belém, Brazil.
¹⁶ Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas (UNICAMP), São Paulo, Brazil; Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. Electronic address: pavargas@fop.unicamp.br.

PMID: 36965251
DOI: 10.1016/j.ijporl.2023.111519

Abstract

Objective: Salivary gland tumors (SGT) are a diverse group of uncommon neoplasms that are rare in pediatric patients. This study aimed to characterize the clinicopathological profile of pediatric patients affected by SGT from a large case series derived from an international group of academic centers.

Study design: A retrospective analysis of pediatric patients with SGT (0-19 years old) diagnosed between 2000 and 2021 from Brazil, South Africa, and the United Kingdom was performed. SPSS Statistics for Windows was used for a quantitative analysis of the data, with a descriptive analysis of the clinicopathological characteristics and the association between clinical variables and diagnoses.

Results: A total of 203 cases of epithelial SGT were included. Females were slightly more commonly (56.5%), with a mean age of 14.1 years. The palate was the most common site (43.5%), followed by the parotid gland (29%), lip (10%), and submandibular gland (7.5%). The predominant clinical presentation was a flesh-colored, smooth, and painless nodule. Pleomorphic adenoma (PA) was the most frequently diagnosed SGT (58.6%), followed by mucoepidermoid carcinoma (MEC) (26.6%). Surgery (90.8%) was the favored treatment option.

Conclusions: Benign SGT in pediatric patients are more commonly benign than malignant tumors. Clinicians should keep PA and MEC in mind when assessing nodular lesions of possible salivary gland origin in pediatric patients.

Keywords: Adolescent; Children; Epidemiology; Head and neck cancer; Salivary glands tumors; Survival.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflict of interest or any commercial associations.

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Epithelial salivary gland tumors in pediatric patients: An international collaborative study

Affiliations

Epithelial salivary gland tumors in pediatric patients: An international collaborative study

Authors

Affiliations

Abstract

Conflict of interest statement

MeSH terms

LinkOut - more resources

Full Text Sources

Medical