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Review
. 2023 Jun;36(3):259-266.
doi: 10.37201/req/118.2022. Epub 2023 Mar 27.

[Macrolide-resistant Mycoplasma pneumoniae: Do we know the situation in Europe?]

[Article in Spanish]
A I Álvaro Varela  1 , A Aguinaga Pérez, A Navascués Ortega, J Castilla Catalán, C Ezpeleta Baquedano
Affiliations
Review

[Macrolide-resistant Mycoplasma pneumoniae: Do we know the situation in Europe?]

[Article in Spanish]
A I Álvaro Varela et al. Rev Esp Quimioter. 2023 Jun.

Abstract
in English, Spanish

Mycoplasma pneumoniae is a bacterium that lacks a cell wall. It produces infections all It produces infections world-wide, in epidemic outbreaks every 4-7 years, or endemically. Its clinical manifestations occur mostly in the respiratory tract and it is a common cause of atypical pneumonia. The treatment is with macrolides, tetracyclines or fluoroquinolones. Since 2000, an increase in resistance to macrolides has been detected worldwide, being more frequent in Asia. In Europe the frequency of resistance ranges between 1% and 25%, depending on the country. Molecular techniques and serology techniques provides very high sensitivity in diagnostic confirmation, being very useful for detecting and controlling M. pneumoniae outbreaks. The detection of resistance to macrolides requires a sequencing technique.

Mycoplasma pneumoniae es una bacteria que carece de pared celular. Produce infecciones en todo el mundo, en brotes epidémicos cada 4-7 años, o en forma endémica. Sus manifestaciones clínicas se producen mayoritariamente en el tracto respiratorio y es una causa común de neumonía atípica. El tratamiento se realiza con macrólidos, tetraciclinas o fluoroquinolonas. Desde el año 2000 se ha detectado un aumento de resistencias a macrólidos a nivel mundial, siendo más frecuentes en Asia. En Europa la frecuencia de resistencias oscila entre el 1% y 25% en diferentes países. La combinación de técnicas moleculares y serológicas aporta una alta sensibilidad en la confirmación diagnóstica, siendo de gran utilidad para la detección y control de brotes de M. pneumoniae. La detección de resistencia a macrólidos requiere una técnica de secuenciación.

Keywords: Mycoplasma pneumoniae; PCR; macrolides; resistance.

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Conflict of interest statement

Los autores declaran no tener conflicto de intereses.

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