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Review
. 2023 Dec 31;19(1):2177484.
doi: 10.1080/15476278.2023.2177484.

The Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications

Joud Mulla  1 , Rohan Katti  1 , Melanie J Scott  1
Affiliations
Review

The Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications

Joud Mulla et al. Organogenesis. .

Abstract

Gasdermin-D (GSDMD) belongs to the Gasdermin family (GSDM), which are pore-forming effector proteins that facilitate inflammatory cell death, also known as pyroptosis. This type of programmed cell death is dependent on inflammatory caspase activation, which cleaves gasdermin-D (GSDMD) to form membrane pores and initiates the release of pro-inflammatory cytokines. Pyroptosis plays an important role in achieving immune regulation and homeostasis within various organ systems. The role of GSDMD in pyroptosis has been extensively studied in recent years. In this review, we summarize the role of GSDMD in cellular and organ injury mediated by pyroptosis. We will also provide an outlook on GSDMD therapeutic targets in various organ systems.

Keywords: GSDMD; Gasdermin-D; inflammsome; organ injury; pyroptosis.

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Conflict of interest statement

No potential conflict of interest was reported by the authors.

Figures

Figure 1.
Figure 1.
GSDMD contributes to organ injury regulation through different pathways: caspase-1, ASC and NLRP3; TLR4-NFκB pathway; Gasdermin-D cleavage, IL1β and IL18 release.
See this image and copyright information in PMC

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