Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr;23(4):393-395.
doi: 10.1016/S1473-3099(23)00053-1. Epub 2023 Feb 14.

Why we need a deeper understanding of the pathophysiology of long COVID

Affiliations

Why we need a deeper understanding of the pathophysiology of long COVID

Akiko Iwasaki et al. Lancet Infect Dis. 2023 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

AI is a principal investigator in a decentralised phase 2 efficacy and safety study of nirmatrelvir and ritonavir in adult participants with long COVID (PAXLC; NCT05668091); is a consultant for RIGImmune, Xanadu Bio, Invisishield, and Paratus Bio; and is the vice president of the American Association of Immunologists. DP declares no competing interest.

Figures

Figure
Figure
Causal model of interaction of viral persistence, autoimmunity, latent viral reactivation, and tissue damage and dysfunction as root cause drivers of Long COVID

Comment in

References

    1. Davis HE, McCorkell L, Vogel JM, Topol EJ. Long COVID: major findings, mechanisms and recommendations. Nat Rev Microbiol. 2023 doi: 10.1038/s41579-022-00846-2. published online Jan 13. - DOI - PMC - PubMed
    1. Stein SR, Ramelli SC, Grazioli A, et al. SARS-CoV-2 infection and persistence in the human body and brain at autopsy. Nature. 2022;612:758–763. - PMC - PubMed
    1. Swank Z, Senussi Y, Manickas-Hill Z, et al. Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae. Clin Infect Dis. 2022 https://doi.org/101.093/cid/ciac722 published online Sept 2. - PMC - PubMed
    1. Klein J, Wood J, Jaycox J, et al. Distinguishing features of long COVID identified through immune profiling. medRxiv. 2022 https://doi.org/101.101/20220.80.92.2278592 published online Aug 10. (preprint). - PMC - PubMed
    1. Su Y, Yuan D, Chen DG, et al. Multiple early factors anticipate post-acute COVID-19 sequelae. Cell. 2022;185:881–895. - PMC - PubMed