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Case Reports
. 2023 Mar 22;10(3):e01011.
doi: 10.14309/crj.0000000000001011. eCollection 2023 Mar.

Primary Pancreatic Undifferentiated Pleomorphic Sarcoma

Mehrie Harshad Patel  1 , Daniela Guerrero Vinsard  2 , Upasana Agrawal  3 , Ryan W Kendziora  4 , Brittany L Siontis  5 , Santhi Swaroop Vege  2 , Seth Sweetser  2
Affiliations
Case Reports

Primary Pancreatic Undifferentiated Pleomorphic Sarcoma

Mehrie Harshad Patel et al. ACG Case Rep J. .

Abstract

Primary pancreatic sarcomas are rare malignancies with an incidence of 0.1%. This case report is of a 48-year-old man who presented with this condition. The patient's treatment plan consisted of distal pancreatectomy and splenectomy with intraoperative immunohistochemistry and adjuvant chemotherapy. To correctly identify and treat undifferentiated pleomorphic sarcoma, a stepwise strategy involving cross-sectional imaging and extensive histopathology analysis is necessary.

Keywords: mass; pancreas; pancreatic malignancy; pancreatic mass; pancreatic neoplasm; sarcoma; undifferentiated; undifferentiated sarcoma.

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Figures

Figure 1.
Figure 1.
Computed tomography scan (before surgical resection).
Figure 2.
Figure 2.
Post-pancreatectomy and splenectomy specimen.
Figure 3.
Figure 3.
Post-pancreatectomy and splenectomy computed tomography scan.
Figure 4.
Figure 4.
(A) Undifferentiated pleomorphic sarcoma of the pancreas, showing extension into peripancreatic adipose tissue (hematoxylin and eosin [H + E], 100×). (B) Representative histomorphology of this patient's undifferentiated pleomorphic sarcoma. This tumor displays predominantly spindled cells with high-grade cytologic features arranged without a consistent architectural pattern. Some cells demonstrate bizarre morphology, and mitotic figures are frequently identified (H + E, 200× magnification).
See this image and copyright information in PMC

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