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. 2023 Jan 3;3(1):1-8.
doi: 10.1158/2767-9764.CRC-22-0410. eCollection 2023 Jan.

Trends of Ovarian Cancer Incidence by Histotype and Race/Ethnicity in the United States 1992-2019

Minh Tung Phung  1 , Celeste Leigh Pearce  1 , Rafael Meza  1   2 , Jihyoun Jeon  1
Affiliations

Trends of Ovarian Cancer Incidence by Histotype and Race/Ethnicity in the United States 1992-2019

Minh Tung Phung et al. Cancer Res Commun. .

Abstract

The effect of risk factors on ovarian cancer differs by histotype, and the prevalence of such risk factors varies by race/ethnicity. It is not clear how ovarian cancer incidence has changed over time by histotype and race/ethnicity. We used the Surveillance, Epidemiology, and End Results Program (SEER-12) 1992-2019 data to examine the trend of ovarian cancer incidence for three histotypes (high-grade serous N = 19,691, endometrioid N = 3,212, and clear cell N = 3,275) and four racial/ethnic groups (Asian/Pacific Islander, Hispanic, non-Hispanic Black, and non-Hispanic White). Joinpoint and age-period-cohort analyses were conducted to analyze ovarian cancer incidence trends. High-grade serous cancer was the most common histotype, but its incidence has significantly decreased over time for all racial/ethnic groups; the decrease was largest for non-Hispanic White women (average annual percent change AAPC during 2010-2019 = -6.1; 95% confidence interval (CI), -8.0 to -4.2). Conversely, clear cell cancer was most common in the Asian/Pacific Islanders, and its incidence has increased over time, particularly among Hispanic and Asian/Pacific Islander women (AAPC during 2010-2019 = 2.8; 95% CI, 0.8 to 4.7, and AAPC = 1.5; 95% CI, 0.7 to 2.2, respectively). Endometrioid cancer incidence has decreased in non-Hispanic White but increased in Hispanic women (AAPC during 2010-2019 = -1.3; 95% CI, -1.9 to -0.8, and AAPC = 3.6; 95% CI, 1.0 to 6.3, respectively). The differential incidence trends by histotype and race/ethnicity underscore the need to monitor incidence and risk factor trends across different groups and develop targeted preventive interventions to reduce the burden of ovarian cancer and disparity by race/ethnicity.

Significance: During 1992-2019, high-grade serous ovarian cancer incidence has decreased while clear cell cancer incidence has increased regardless of race/ethnicity. Endometrioid cancer incidence has decreased in non-Hispanic White but increased in Hispanic women. Differential ovarian cancer incidence trends highlight the need for targeted preventive interventions by histotype and race/ethnicity.

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Conflict of interest statement

C.L. Pearce reports grants from NCI during the conduct of the study. No disclosures were reported by the other authors.

Figures

FIGURE 1
FIGURE 1
ASIR (per 1,000,000) of ovarian cancer by histotype and race/ethnicity, SEER-12, 1992–2019. Note that the y-axis scales are different across the panels.
FIGURE 2
FIGURE 2
Cohort effects from the age-cohort models, SEER-12, 1992–2019.
See this image and copyright information in PMC

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