Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Mar 20:16:187-192.
doi: 10.2147/IMCRJ.S389204. eCollection 2023.

Hydrocephalus Caused by Tuberculous Meningitis in an Immunocompetent Young Adult: A Case Report

Affiliations
Case Reports

Hydrocephalus Caused by Tuberculous Meningitis in an Immunocompetent Young Adult: A Case Report

Rizaldy Taslim Pinzon et al. Int Med Case Rep J. .

Abstract

Background: Despite improved medical management, meningeal tuberculosis mortality and other outcomes have changed slightly over time due to a delay in diagnosis and treatment. This study reports a rare case of tuberculous meningitis in an immunocompetent host, calling into question the commonly held belief that tuberculous meningitis is a disease of immunocompromised individuals.

Case presentation: A 26-year-old male with no significant past medical history, tuberculosis, or indications of immunological compromise, was admitted to our hospital with a fever and altered mental status. He was drowsy, febrile (temperature of 38°C), had a heart rate of 110 beats per minute, and showed mild neck stiffness but no meningeal sign. A lumbar puncture on the third day of admission suggested tuberculous meningitis. He was treated for tuberculosis meningitis, and his condition slightly improved. However, the patient's condition suddenly worsened, and a repeat contrast computed tomography (CT) of the brain showed the development of ventriculomegaly and basilar enhancement. Insertion of an emergency ventriculoperitoneal shunt was performed; however, the patient died ten days after hospital admission.

Conclusion: We report a fatal case of tuberculous meningitis in an immunocompetent patient. Healthcare practitioners must be trained to identify and diagnose tuberculous meningitis promptly. Early treatment of tuberculous meningitis based on clinical diagnosis and symptoms improves clinical outcomes.

Keywords: immunocompetent; meningitis; tuberculosis.

PubMed Disclaimer

Conflict of interest statement

The authors disclose that they have no competing interests.

Figures

Figure 1
Figure 1
The patient’s chest x-ray indicated no pathology or localized consolidation.
Figure 2
Figure 2
The initial computed tomography (CT) scan does not show any hydrocephalus and oedema.
Figure 3
Figure 3
A repeat contrast CT of the brain showed enhancement in basal cistern and hydrocephalus.

References

    1. Chakaya J, Khan M, Ntoumi F, et al. Global tuberculosis report 2020 - reflections on the global TB burden, treatment and prevention efforts. Int J Infect Dis. 2021;113(Suppl1):S7–S12. doi:10.1016/j.ijid.2021.02.107 - DOI - PMC - PubMed
    1. Marx GE, Chan ED. Tuberculous meningitis: diagnosis and treatment overview. Tuberc Res Treat. 2011;2011:798764. doi:10.1155/2011/798764 - DOI - PMC - PubMed
    1. Verma R, Patil TB, Lalla R. Disseminated tuberculosis manifesting as pulmonary, meningeal and spinal tuberculosis in an immunocompetent patient. BMJ Case Rep. 2012;2012:bcr2012007778. doi:10.1136/bcr-2012-007778 - DOI - PMC - PubMed
    1. Akyol AG, Nazliel B, Oner Y, Erdem O. Chronic bilateral hearing loss in an immunocompetent patient. An atypical course of tuberculous meningitis. Neurosciences. 2014;19(4):322–325. - PMC - PubMed
    1. Marais S, Thwaites G, Schoeman JF, et al. Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infect Dis. 2010;10(11):803–812. doi:10.1016/S1473-3099(10)70138-9 - DOI - PubMed

Publication types