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. 2023 Mar 1;10(3):ofad112.
doi: 10.1093/ofid/ofad112. eCollection 2023 Mar.

Re-emergence of Parechovirus: 2017-2022 National Trends of Detection in Cerebrospinal Fluid

Lili Tao  1 , Romney M Humphries  1 , Ritu Banerjee  2 , David C Gaston  1
Affiliations

Re-emergence of Parechovirus: 2017-2022 National Trends of Detection in Cerebrospinal Fluid

Lili Tao et al. Open Forum Infect Dis. .

Abstract

Increasing parechovirus (PeV) infections prompted a Centers for Disease Control and Prevention Health Advisory in July 2022. We retrospectively assessed national PeV trends in cerebrospinal fluid and observed unexpected viral dynamics from 2020 to 2022 with regional variance. These findings may be due to mitigation strategies aimed at severe acute respiratory syndrome coronavirus 2. PeV testing can benefit ill patients, particularly children.

Keywords: Epidemiology; Meningitis; Pediatrics.

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Conflict of interest statement

Potential conflicts of interest. D.C.G.: reagents from IDbyDNA, Inc., and Illumina, Inc.; consulting for bioMérieux. R.M.H.: research support from bioMérieux; consulting for bioMérieux. The other authors report no potential conflicts of interest.

Figures

Figure 1.
Figure 1.
National positive rate of Parechovirus, Enterovirus, and herpes simplex virus 2 from a multiplex molecular meningitis/encephalitis panel from January 2017 to July 2022. A, Positive rate of Parechovirus by time. B, Positive rate of Parechovirus in “circulating” years. C, Positive rate of Enterovirus by time. D, Positive rate of herpes simplex virus 2 by time. E, Positive rate of Parechovirus in different regions by year. Data at the top of the columns are labeled as number of Parechovirus positive tests/number of total tests for each year. aIncomplete data for 2022; data from January 1 to September 31 were collected.
See this image and copyright information in PMC

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