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Observational Study
. 2023 Mar 10:11:1115055.
doi: 10.3389/fpubh.2023.1115055. eCollection 2023.

Characterization and susceptibility of non-albicans Candida isolated from various clinical specimens in Lebanese hospitals

Rola Husni  1   2 , Maroun Bou Zerdan  3 , Nadia Samaha  4 , Mariana Helou  1   2 , Youssef Mahfouz  5 , Rim Saniour  5 , Sawsan Hourani  5 , Harout Kolanjian  1   2 , Claude Afif  6 , Eid Azar  6 , Tamima El Jisr  7 , Jacques Mokhbat  1   2 , Emma Abboud  8 , Rita Feghali  9 , Edmond Abboud  10 , Hiam Matta  11 , Gilbert Karayakouboglo  12 , Madonna Matar  13 , Rima Moghnieh  1   2 , Ziad Daoud  14   15
Affiliations
Observational Study

Characterization and susceptibility of non-albicans Candida isolated from various clinical specimens in Lebanese hospitals

Rola Husni et al. Front Public Health. .

Abstract

Background: Invasive fungal infections have presented a challenge in treatment. In the past, it was known that the frontrunner in such infections is Candida albicans with little emphasis placed on non-albicans Candida species (NAC). Studies worldwide have shown a rise in fungal infections attributed to non-albicans Candida species. The aim of this study is to describe the epidemiology of NAC infections along with an overview of resistance in Lebanese hospitals.

Methods: This is a two-year observational multi-central descriptive study. Between September 2016 and May of 2018, a total of 1000 isolates were collected from 10 different hospitals distributed all over the country. For the culture, Sabouraud Dextrose Agar was used. Antifungal Susceptibility was evaluated by determining the Minimum Inhibitory Concentration (MIC) in broth (microdilution) of the different antifungal treatments.

Results: Out of the 1000 collected isolates, Candida glabrata, being the most isolated species (40.8%), followed by Candida tropicalis: 231(23.1%), Candida parapsilosis: 103(10.3%), and other NAC species at lower percentage. Most of these isolates (88.67%) were susceptible to posaconazole, 98.22% were susceptible to micafungin, and 10% were susceptible to caspofungin.

Conclusion: The change of etiology of fungal infections involving a significant increase in NAC cases is alarming due to the different antifungal susceptibility patterns and the lack of local guidelines to guide the treatment. In this context, proper identification of such organisms is of utmost importance. The data presented here can help in establishing guidelines for the treatment of candida infections to decrease morbidity and mortality. Future surveillance data are needed.

Keywords: fungal infection; infection; microbiology; non-albicans Candida; pathogens.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Candida spp. isolated from various clinical specimens.
See this image and copyright information in PMC

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