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. 2023 Mar 10:10:1076301.
doi: 10.3389/fnut.2023.1076301. eCollection 2023.

The association between visceral adiposity index and decreased renal function: A population-based study

Zheng Qin  1 , Xinyang Chen  1 , Jiantong Sun  1 , Luojia Jiang  2
Affiliations

The association between visceral adiposity index and decreased renal function: A population-based study

Zheng Qin et al. Front Nutr. .

Abstract

Aims: We aimed to investigate the association of visceral adiposity index (VAI) with decreased renal function in US adults.

Design and methods: Cross-sectional data were analyzed for 35,018 adults in the National Health and Nutrition Examination Survey (NHANES) 2005-2018. VAI was determined using waist circumference, body mass index (BMI), triglycerides (TGs) and high-density lipoprotein-cholesterol. Albuminuria was defined as urinary albumin-to-creatinine ratio (ACR) >30 mg/g. A low estimated-glomerular filtration rate (eGFR) was defined as an eGFR lower than 60 ml/min/1.73 m2. Chronic kidney disease (CKD) was defined as either albuminuria or low-eGFR. A multivariable logistic regression analysis was utilized to explore the relationship of VAI with albuminuria, low-eGFR and CKD. Subgroup analysis and interaction tests were also conducted.

Results: A total of 35,018 participants were enrolled with albuminuria, low-eGFR, and CKD prevalence rates of 5.18, 6.42, and 10.62%, respectively, which increased with the higher VAI tertiles. After full adjustment, a positive association of VAI with albuminuria (OR = 1.03, 95% CI: 1.00, 1.06) and CKD (OR = 1.04, 95% CI: 1.02, 1.06) was observed. Participants in the highest VAI tertile had a significantly 30% increased risk for albuminuria (OR = 1.30, 95% CI: 1.07, 1.58) and a 27% increased risk for CKD (OR = 1.27, 95% CI: 1.08, 1.49) compared with those in the lowest VAI tertile. No statistically significant association between VAI and low-eGFR was detected. Subgroup analysis and the interaction term indicated that there was no significant difference among different stratifications.

Conclusion: Visceral adiposity accumulation evaluating by VAI was associated with increased likelihood of the decline in renal function.

Keywords: albuminuria; chronic kidney disease; cross-sectional study; estimated-glomerular filtration rate; visceral adiposity index.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flowchart of the sample selection from NHANES 2005–2018.
FIGURE 2
FIGURE 2
Subgroup analysis for the association between VAI and albuminuria.
FIGURE 3
FIGURE 3
Subgroup analysis for the association between VAI and low-eGFR.
FIGURE 4
FIGURE 4
Subgroup analysis for the association between VAI and CKD.
See this image and copyright information in PMC

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