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Review
. 2023 Jun 28;11(3):670-674.
doi: 10.14218/JCTH.2022.00362. Epub 2023 Jan 19.

Impact of Helicobacter pylori Infection on the Pathogenesis and Management of Nonalcoholic Fatty Liver Disease

Marianna G Mavilia-Scranton  1 , George Y Wu  1 , Murali Dharan  1
Affiliations
Review

Impact of Helicobacter pylori Infection on the Pathogenesis and Management of Nonalcoholic Fatty Liver Disease

Marianna G Mavilia-Scranton et al. J Clin Transl Hepatol. .

Abstract

Helicobacter pylori (H. pylori) infection is widely prevalent worldwide. H. pylori infection has been reported to be a risk factor for the development of insulin resistance, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), liver fibrosis, and cirrhosis. Because treatment for NAFLD, other than weight loss is limited, the treatment for H. pylori infection is well established. It is important to determine whether screening and treatment for H. pylori infection should be considered in patients with no gastrointestinal symptoms. The aim of this mini-review is to evaluate the association between H. pylori infection and NAFLD including epidemiology, pathogenesis, and the evidence for H. pylori infection as a modifiable risk factor for preventing or treating NAFLD.

Keywords: Helicobacter pylori; Hepatic fibrosis; Hepatic steatosis; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis.

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Conflict of interest statement

GYW has been an editor-in-chief of Journal of Clinical and Translational Hepatology since 2013. The other authors have no conflict of interests related to this publication.

Figures

Fig. 1
Fig. 1. Possible mechanisms of H. pylori infection on the development of NAFLD.
FFA, free fatty acid; HbA1c, hemoglobin A1c; LDL-C, low density lipoprotein cholesterol; NAFLD, nonalcoholic fatty liver disease.
See this image and copyright information in PMC

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