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Review
. 2023 Mar 22:15:17588359231161418.
doi: 10.1177/17588359231161418. eCollection 2023.

Short-term fasting and fasting mimicking diets combined with chemotherapy: a narrative review

Joachim Kikomeko  1   2 , Tim Schutte  3   2 , Merel J M van Velzen  4   2 , Rianne Seefat  5 , Hanneke W M van Laarhoven  4   2
Affiliations
Review

Short-term fasting and fasting mimicking diets combined with chemotherapy: a narrative review

Joachim Kikomeko et al. Ther Adv Med Oncol. .

Abstract

Many patients with cancer search for and use alternative and complementary treatments, aiming to improve the effectiveness of their anticancer treatment and a reduction in treatment-associated side effects. Short-term fasting (STF) and fasting mimicking diets (FMDs) are among the most commonly used dietary interventions. In recent years, different trials have reported the promising results of dietary interventions in combination with chemotherapy, in terms of slowing down tumor growth and reduction in chemotherapy-related side effects. In this narrative review, we identify and describe the current evidence about feasibility and effects of STF and FMDs in cancer patients receiving chemotherapy. The studies that examined the effects of STF when combined with chemotherapy suggest potential benefits regarding reduction in side effects and improved quality of life. We also conclude with a list of well-designed studies that are still recruiting patients, examining the long-term effects of STF.

Keywords: chemotherapy; fasting mimicking diets; short-term fasting.

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Conflict of interest statement

Hanneke W. M. van Laarhoven: Consultant or advisory role: Amphera, AstraZeneca, Beigene, BMS, Daiichy-Sankyo, Dragonfly, Eli Lilly, MSD, Nordic Pharma, Servier Research funding and/or medication supply: Bayer, BMS, Celgene, Janssen, Incyte, Eli Lilly, MSD, Nordic Pharma, Philips, Roche, Servier Speaker role: Astellas, Benecke, Daiichy-Sankyo, JAAP, Medtalks, Novartis, Travel Congress Management B.V.

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