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Review
. 2023 Mar 14;8(3):294-301.
doi: 10.1016/j.ncrna.2023.03.003. eCollection 2023 Sep.

The role of long non-coding RNAs in carbohydrate and fat metabolism in the liver

Valentin Kudriashov  1 , Albert Sufianov  2   3 , Andrey Mashkin  2 , Aferin Beilerli  4 , Tatiana Ilyasova  5 , Yanchao Liang  6 , Sergey Lyulin  7 , Ozal Beylerli  2
Affiliations
Review

The role of long non-coding RNAs in carbohydrate and fat metabolism in the liver

Valentin Kudriashov et al. Noncoding RNA Res. .

Abstract

The metabolism of carbohydrates and lipids (fat) in the liver is closely interconnected both in physiological conditions and in pathology. This relationship in the body is possible due to the regulation by many factors, including epigenetic ones. Histone modifications, DNA methylation, and non-coding RNAs are considered to be the main epigenetic factors. Non-coding RNAs (ncRNAs) refers to ribonucleic acid (RNA) molecules that do not code for a protein. They cover a huge number of RNA classes and perform a wide range of biological functions such as regulating gene expression, protecting the genome from exogenous DNA, and directing DNA synthesis. One such class of ncRNAs that has been extensively studied are long non-coding RNAs (lncRNAs). The important role of lncRNAs in the formation and maintenance of normal homeostasis of biological systems, as well as participation in many pathological processes, has been proven. The results of recent studies indicate the importance of lncRNAs in lipid and carbohydrate metabolism. Modifications of lncRNAs expression can lead to disruption of biological processes in tissues, including fat and protein, such as adipocyte proliferation and differentiation, inflammation, and insulin resistance. Further study of lncRNAs made it possible to partly determine the regulatory mechanisms underlying the formation of an imbalance in carbohydrate and fat metabolism individually and in their relationship, and the degree of interaction between different types of cells involved in this process. This review will focus on the function of lncRNAs and its relation to hepatic carbohydrate and fat metabolism and related diseases in order to elucidate the underlying mechanisms and prospects for studies with lncRNAs.

Keywords: Carbohydrate metabolism; Fat metabolism; Liver; Signal pathways; lncRNAs.

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Conflict of interest statement

The authors declare that no conflicts of interest exist.

Figures

Fig. 1
Fig. 1
Functions of long non-coding RNAs.
See this image and copyright information in PMC

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