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. 2023;5(1):109.
doi: 10.1007/s42399-023-01451-x. Epub 2023 Mar 22.

FAR Ratio as Prognostic Biomarker in AMI

Ali Muhtaroğlu  1 , Recayi Çapoğlu  2 , Furkan Ali Uygur  1 , Ahmet Tarık Harmantepe  2 , Zülfü Bayhan  3 , Emre Gönüllü  4
Affiliations

FAR Ratio as Prognostic Biomarker in AMI

Ali Muhtaroğlu et al. SN Compr Clin Med. 2023.

Abstract

Acute mesenteric ischemia (AMI) is a vascular emergency resulting from decreased blood flow caused by the occlusion of the mesenteric vessels, hypoperfusion, or vasospasm. This study aimed to investigate the prognostic value of the fibrinogen-to-albumin (FAR) ratio in patients with acute mesenteric ischemia. A total of 91 patients were enrolled in the study. Patients' demographics such as age and gender, pre- and postoperative hemoglobin, CRP, white blood cell (WBC), neutrophils, preoperative lymphocyte, alanine transaminase (ALT), aspartate transaminase (AST), thrombocytes, and postoperative D-dimer values were recorded. In addition, pre- and postoperative fibrinogen and albumin levels were recorded, and FAR was calculated. Patients were divided into two groups, survivors and non-survivors. The mean pre- and postoperative fibrinogen levels were statistically significantly higher in the non-survivor group than in the survivor group (p < 0.001). The mean pre- and postoperative albumin levels were significantly lower in the non-survivors than in the survivors (p = 0.059, p < 0.001; respectively). The mean pre- and postoperative FAR ratios were considerably higher in the non-survivor than in the survivor groups (p < 0.001). The change between pre- and postoperative fibrinogen, albumin, and FAR values was statistically significant between the non-survivors and the survivors (for all, p < 0.05). The preoperative and postoperative fibrinogen levels were significantly lower, and albumin levels were significantly higher in the survivor compared to the non-survivor patients with AMI. Furthermore, the preoperative and postoperative FAR ratio was significantly higher in the non-survivors. The FAR ratio may be a valuable prognostic biomarker for patients with AMI.

Keywords: Acute mesenteric ischemia; Albumin; Fibrinogen; Fibrinogen-to-albumin ratio; Prognosis.

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Conflict of interest statement

Conflict of InterestThe authors declare no competing interests.

Figures

Fig 1
Fig 1
Distribution of the patients according to the groups
Fig. 2
Fig. 2
Pre- and postoperative change in the mean fibrinogen value according to the group
Fig. 3
Fig. 3
Pre- and postoperative change in the mean albumin value according to the groups
Fig. 4
Fig. 4
Pre- and postoperative change in the mean FAR value according to the groups
See this image and copyright information in PMC

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