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Comment
. 2023 Jul;202(1):9-10.
doi: 10.1111/bjh.18776. Epub 2023 Mar 27.

Secondary spleen in immune thrombocytopenia: Not so accessory after all…

Rick Kapur  1 , Sylvain Audia  2
Affiliations
Comment

Secondary spleen in immune thrombocytopenia: Not so accessory after all…

Rick Kapur et al. Br J Haematol. 2023 Jul.

Abstract

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by an isolated thrombocytopenia. The pathophysiology is complex but involves platelet-autoantibodies and/or cytotoxic T cells, with the spleen playing an important regulatory role. Accessory spleen (AcS) may possibly contribute to ITP relapse following splenectomy; however, the microenvironment of AcS has not been directly compared to the main spleen. Pizzi et al. conducted a histological study of adult ITP patients where they compared eight matched AcS to main spleens, and they observed a similar immunological composition in both groups. This supports the possibility of AcS-mediated ITP relapse post splenectomy. Commentary on: Pizzi et al. Accessory spleens recapitulate the immune microenvironment of the main spleen in immune thrombocytopenia. Br J Haematol 2023;202:147-152.

Keywords: accessory spleen; immune thrombocytopenia; secondary spleen.

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References

REFERENCES

    1. Zufferey A, Kapur R, Semple JW. Pathogenesis and therapeutic mechanisms in immune thrombocytopenia (ITP). J Clin Med. 2017;6(2):16.
    1. Audia S, Mahevas M, Nivet M, Ouandji S, Ciudad M, Bonnotte B. Immune thrombocytopenia: recent advances in pathogenesis and treatments. Hemasphere. 2021;5(6):e574.
    1. Semple JW, Rebetz J, Maouia A, Kapur R. An update on the pathophysiology of immune thrombocytopenia. Curr Opin Hematol. 2020;27:423-9.
    1. Aslam R, Kapur R, Segel GB, Guo L, Zufferey A, Ni H, et al. The spleen dictates platelet destruction, anti-platelet antibody production and lymphocyte distribution patterns in a murine model of immune thrombocytopenia (ITP). Exp Hematol. 2016;44:924-930.e1.
    1. Pizzi M, Vianello F, Binotto G, Vianelli N, Carli G, Auteri G, et al. Thrombopoietin receptor agonists increase splenic regulatory T-cell numbers in immune thrombocytopenia. Br J Haematol. 2022;198(5):916-22.

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