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Comment
. 2023 Aug 1;14(8):556-559.
doi: 10.1093/procel/pwad015.

Emerging applications of tumour-educated platelets in the detection and prognostication of ovarian cancer

Jiewei Zhu  1   2 , Vasily Giannakeas  1 , Steven A Narod  1   3   4 , Mohammad R Akbari  1   3   4
Affiliations
Comment

Emerging applications of tumour-educated platelets in the detection and prognostication of ovarian cancer

Jiewei Zhu et al. Protein Cell. .
No abstract available

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Conflict of interest statement

None declared.

Figures

Figure 1.
Figure 1.
Three main proposed mechanisms of action for tumour-educated platelets (TEPs). Cancer cells induce platelet activation through education to generate TEPs. TEPs coat CTCs which promote immune escape, allow tumour cells to intravasate through undergoing EMT and promote tumour cell invasion and metastasis through p38MAPK-MMP-9 pathway regulation. CTC, circulating tumour cell; EMT, epithelial-to-mesenchymal transition; MMP-9, matrix metalloproteinase 9; TBK1, TANK Binding Kinase 1; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells.
See this image and copyright information in PMC

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References

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