Response by Dhingra et al to Letter Regarding Article, "Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy"

Rimpy Dhingra^{1

2}, Ali Javaheri³, Abhinav Diwan³, Lorrie A Kirshenbaum^{1

2

4}

Affiliations

¹ The Institute of Cardiovascular Sciences, St Boniface Hospital Albrechtsen Research Centre, Winnipeg, Canada (R.D., L.A.K.).
² Departments of Physiology and Pathophysiology (R.D., L.A.K.), Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
³ Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO (A.J., A.D.).
⁴ Pharmacology and Therapeutics (L.A.K.), Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Comment

Rimpy Dhingra et al. Circulation. 2023.

. 2023 Mar 28;147(13):1051-1052.

doi: 10.1161/CIRCULATIONAHA.123.063546. Epub 2023 Mar 27.

Rimpy Dhingra^{1

2}, Ali Javaheri³, Abhinav Diwan³, Lorrie A Kirshenbaum^{1

2

4}

¹ The Institute of Cardiovascular Sciences, St Boniface Hospital Albrechtsen Research Centre, Winnipeg, Canada (R.D., L.A.K.).
² Departments of Physiology and Pathophysiology (R.D., L.A.K.), Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
³ Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO (A.J., A.D.).
⁴ Pharmacology and Therapeutics (L.A.K.), Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

No abstract available

Comment on

Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy.
Dhingra R, Rabinovich-Nikitin I, Rothman S, Guberman M, Gang H, Margulets V, Jassal DS, Alagarsamy KN, Dhingra S, Valenzuela Ripoll C, Billia F, Diwan A, Javaheri A, Kirshenbaum LA. Dhingra R, et al. Circulation. 2022 Sep 20;146(12):934-954. doi: 10.1161/CIRCULATIONAHA.121.058411. Epub 2022 Aug 19. Circulation. 2022. PMID: 35983756 Free PMC article.

1. Dhingra R, Rabinovich-Nikitin I, Rothman S, Guberman M, Gang H, Margulets V, Jassal DS, Alagarsamy KN, Dhingra S, Valenzuela Ripoll C, Billia F, Diwan A, Javaheri A, Kirshenbaum LA. Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy. Circulation. 2022; 146:934–954. doi: 10.1161/CIRCULATIONAHA.121.058411 - DOI - PMC - PubMed
1. Siegmund D, Wagner J, Wajant H. TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer. Cancers (Basel). 2022; 14:4055–4083. doi: 10.3390/cancers14164055. - DOI - PMC - PubMed
1. Gang H, Dhingra R, Lin J, Hai Y, Aviv Y, Margulets V, Hamedani M, Thanasupawat T, Leygue E, Klonisch T, Davie JR, Kirshenbaum LA. PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival. J Cell Biol. 2015; 210:1101–1115. doi: 10.1083/jcb.201504047. - DOI - PMC - PubMed
1. Ichikawa Y, Ghanefar M, Bayeva M, Wu R, Khechaduri A, Naga Prasad SV, Mutharasan RK, Naik TJ, Ardehali H. Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. J Clin Invest. 2014; 124:617–630. doi: 10.1172/JCI72931. - DOI - PMC - PubMed
1. Dhingra R, Margulets V, Chowdhury SR, Thliveris J, Jassal D, Fernyhough P, Dorn GW 2nd, Kirshenbaum LA. Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling. Proc Natl Acad Sci U S A. 2014;111: E5537–5544. doi: 10.1073/pnas.1414665111. - DOI - PMC - PubMed