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Comment
. 2023 Apr 4;120(14):e2302320120.
doi: 10.1073/pnas.2302320120. Epub 2023 Mar 27.

Lipid rafts, Rab GTPases, and a late endosomal checkpoint for plasma membrane recycling

Ilsa-Maria Daumann  1 , P Robin Hiesinger  1
Affiliations
Comment

Lipid rafts, Rab GTPases, and a late endosomal checkpoint for plasma membrane recycling

Ilsa-Maria Daumann et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Proposed roles of ordered and disordered membrane domains in intracellular protein sorting. Gradients from more to less-ordered membrane domains have been proposed for the secretory pathways (ER: more disordered; PM: more ordered) and the recycling pathway (PM: more ordered; lysosome: less ordered). However, lipid microdomains or nanodomains are highly dynamic and heterogeneous to various degrees in all membranes. Diaz-Rohrer et al. now provide evidence for the late endosome as a membrane protein sorting station in the recycling pathway. The authors report that palmitoylated Rab3 functions as a regulator for the recycling of membrane probes in ordered lipid domains, while membrane probes associated with disordered domains traffic to the lysosome. ER: endoplasmic reticulum.
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