Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Apr 4;120(14):e2302320120.
doi: 10.1073/pnas.2302320120. Epub 2023 Mar 27.

Lipid rafts, Rab GTPases, and a late endosomal checkpoint for plasma membrane recycling

Ilsa-Maria Daumann  1 , P Robin Hiesinger  1
Affiliations
Comment

Lipid rafts, Rab GTPases, and a late endosomal checkpoint for plasma membrane recycling

Ilsa-Maria Daumann et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Proposed roles of ordered and disordered membrane domains in intracellular protein sorting. Gradients from more to less-ordered membrane domains have been proposed for the secretory pathways (ER: more disordered; PM: more ordered) and the recycling pathway (PM: more ordered; lysosome: less ordered). However, lipid microdomains or nanodomains are highly dynamic and heterogeneous to various degrees in all membranes. Diaz-Rohrer et al. now provide evidence for the late endosome as a membrane protein sorting station in the recycling pathway. The authors report that palmitoylated Rab3 functions as a regulator for the recycling of membrane probes in ordered lipid domains, while membrane probes associated with disordered domains traffic to the lysosome. ER: endoplasmic reticulum.
See this image and copyright information in PMC

Comment on

References

    1. Simons K., Ikonen E., Functional rafts in cell membranes. Nature 387, 569–572 (1997). - PubMed
    1. Levental I., Levental K. R., Heberle F. A., Lipid rafts: Controversies resolved, mysteries remain. Trends Cell Biol. 30, 341–353 (2020). - PMC - PubMed
    1. Kinnun J. J., et al. , Biophysical studies of lipid nanodomains using different physical characterization techniques. Biophys. J., 10.1016/j.bpj.2023.01.024 (2023). - DOI - PMC - PubMed
    1. Regen S. L., The origin of lipid rafts. Biochemistry 59, 4617–4621 (2020). - PubMed
    1. Gebhardt C., Gruler H., Sackmann E., On domain structure and local curvature in lipid bilayers and biological membranes. Z. Naturforsch. C Biosci. 32, 581–596 (1977). - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources