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Review
. 2023 Mar;37(6):e24872.
doi: 10.1002/jcla.24872. Epub 2023 Mar 27.

Adipose tissue and hematopoiesis: Friend or foe?

Na He  1   2 , Min Liu  1 , Yue Wu  1
Affiliations
Review

Adipose tissue and hematopoiesis: Friend or foe?

Na He et al. J Clin Lab Anal. 2023 Mar.

Abstract

Aim: Hematopoietic stem cells are the origin of all hematopoietic cells. They have the self-renewal ability and can differentiate into various blood cells. In physiological state, most of the hematopoietic stem cells are dormant, and only a few cells proliferate to maintain hematopoietic homeostasis.

Methods: This precise steady-state maintenance is regulated by complex mechanisms. Bone marrow adipocytes make up half of all cells in the bone marrow cavity, a feature that has attracted the attention of researchers from multiple fields. The adipocyte density within marrow increases during aging and obesity.

Results: Recent studies have shown that bone marrow adipocytes play important roles in regulating hematopoiesis, but the effects of bone marrow adipocytes on hematopoiesis are often conflicting. Bone marrow adipocytes, participating in the formation of bone marrow hematopoietic microenvironment, influence hematopoiesis positively or negatively. In addition, other adipose tissue, especially white adipose tissue, also regulates hematopoiesis.

Conclusion: In this review, we describe the role of adipose tissue in hematological malignancies, which may be useful for understanding hematopoiesis and the pathogenesis of related diseases.

Keywords: adipose tissue; bone marrow; hematopoiesis.

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Conflict of interest statement

The authors declare there is no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Phenotypes of WAT, BAT, Beige, Pink, and MAT. The typical phenotypic appearance of WAT, BAT, Beige, Pink, and MAT is described with the different functions of the respective adipose tissue.
FIGURE 2
FIGURE 2
Diagram of hematopoietic stem cell differentiation and development. Hematopoietic stem cells proliferate and differentiate into different progenitor cells which then differentiate into mature blood cells with different morphologies. The curved arrow indicates that cell self‐renewal. Megakaryocyte/erythroid progenitor, BFU‐E; colony‐forming unit‐erythroid; CFU‐E; megakaryocyte colony‐forming cells; Eo‐CFC; granulocyte/macrophage progenitor cell; G‐CFC; macrophage colony‐forming cells; GM‐CFC; granulocyte‐colony forming cells; GMP; burst‐forming unit erythroid; M‐CFC; mast cell progenitors, mast‐CFC; Meg‐CFC; eosinophil colony‐forming cell; MEP; granulocyte‐macrophage progenitor.
See this image and copyright information in PMC

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