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. 2023 Jan-Dec:22:15330338231164875.
doi: 10.1177/15330338231164875.

Pancreatitis and Pancreatic Cancer Risk

Dong-Mei Ma  1 , Xiao-Wu Dong  2   3 , Xiao Han  1 , Zhi Ling  1 , Guo-Tao Lu  2   3 , Yun-Yun Sun  2   3 , Xu-Dong Yin  1
Affiliations

Pancreatitis and Pancreatic Cancer Risk

Dong-Mei Ma et al. Technol Cancer Res Treat. 2023 Jan-Dec.

Abstract

Purpose: The present retrospective study aimed to explore the relationship between pancreatitis and pancreatic cancer in the population cohort of the UK Biobank (UKB) (https://www.ukbiobank.ac.uk). Methods: From the 500 thousand population cohort of UKB, according to the age and gender of patients with pancreatic cancer 1:10, matching the control without pancreatic cancer, the binary Logistic regression model was used to analyze the relationship between pancreatitis and pancreatic cancer, and subgroup analyses were used to identify potential effect modifiers. Results: A total of 1538 patients with pancreatic cancer were compared with 15 380 controls. In the fully adjusted model, patients with pancreatitis had a significantly increased risk of pancreatic cancer compared with no pancreatitis. The risk of pancreatitis and pancreatic cancer increased with the age of pancreatitis, and the risk of pancreatic cancer was highest in the 61 to 70 age group. In addition, in the first 3 years of acute pancreatitis, the risk of pancreatic cancer increased significantly with the increase in the duration of the disease (odds ratio [OR] 29.13, 95% confidence interval [CI]: 16.34-51.93), after 3 years, the trend of increase decreased. After more than 10 years, there was no significant correlation between the risk of acute pancreatitis and pancreatic cancer. However, patients with chronic pancreatitis were significantly associated with an increased risk of pancreatic cancer only in the first 3 years (OR 28.14, 95% CI: 14.86-53.31). Conclusion: Pancreatitis may associate with an increased risk of pancreatic cancer. The older the age of pancreatitis, the higher the risk of pancreatic cancer. The risk of pancreatic cancer increases significantly in the first 3 years of the course of pancreatitis. This may provide an alternative strategy for the early identification of individuals at high risk of pancreatic cancer.

Keywords: UKB; acute pancreatitis; chronic pancreatitis; pancreatic cancer; pancreatitis.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Screening process and results of research objects. Abbreviations: PC, pancreatic cancer; UKB, UK Biobanks.
See this image and copyright information in PMC

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