Brain Shrinkage in Anti-β-Amyloid Alzheimer Trials: Neurodegeneration or Pseudoatrophy?

Affiliations

¹ From the Department of Radiology and Nuclear Medicine (F.B.), Amsterdam University Medical Center, VU Medical Center, Amsterdam, Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, UK; Department of Neurology (D.S.K.) and Mayo Clinic Alzheimer Research Center, Mayo Clinic, Rochester MN. f.barkhof@amsterdamumc.nl.
² From the Department of Radiology and Nuclear Medicine (F.B.), Amsterdam University Medical Center, VU Medical Center, Amsterdam, Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, UK; Department of Neurology (D.S.K.) and Mayo Clinic Alzheimer Research Center, Mayo Clinic, Rochester MN.

Editorial

Frederik Barkhof et al. Neurology. 2023.

. 2023 May 16;100(20):941-942.

doi: 10.1212/WNL.0000000000207268. Epub 2023 Mar 27.

¹ From the Department of Radiology and Nuclear Medicine (F.B.), Amsterdam University Medical Center, VU Medical Center, Amsterdam, Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, UK; Department of Neurology (D.S.K.) and Mayo Clinic Alzheimer Research Center, Mayo Clinic, Rochester MN. f.barkhof@amsterdamumc.nl.
² From the Department of Radiology and Nuclear Medicine (F.B.), Amsterdam University Medical Center, VU Medical Center, Amsterdam, Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, UK; Department of Neurology (D.S.K.) and Mayo Clinic Alzheimer Research Center, Mayo Clinic, Rochester MN.

No abstract available

Comment on

Accelerated Brain Volume Loss Caused by Anti-β-Amyloid Drugs: A Systematic Review and Meta-analysis.
Alves F, Kalinowski P, Ayton S. Alves F, et al. Neurology. 2023 May 16;100(20):e2114-e2124. doi: 10.1212/WNL.0000000000207156. Epub 2023 Mar 27. Neurology. 2023. PMID: 36973044 Free PMC article.