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Comment
. 2023 Mar 27;8(1):140.
doi: 10.1038/s41392-023-01412-9.

The loss of epigenetic information: not only consequences but a cause of mammalian aging

Chen Pan  1 , Fangfang Zhou  2 , Long Zhang  3   4
Affiliations
Comment

The loss of epigenetic information: not only consequences but a cause of mammalian aging

Chen Pan et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Diagram and molecular mechanisms underlying the ICE mouse models. a left, the Inducible Change to the Epigenome (ICE) system. In this gene-engineering mouse model, recombined protein of endonuclease I-PpoI and Cre-ERT2 is under control of tamoxifen. If tamoxifen is added, I-PpoI will enter nucleus to create DNA double strand break which then will be repaired through faithful DNA repair pathway. right, aging phenotypes of ICE models. b Epigenetic landscapes changes in ICE model, including the erosion of H3K27ac, remodeling chromatin contact, and aberrant super enhancers. c The diagram of cell rejuvenation. Briefly, overexpression Oct4/Sox2/Klf4 in ICE/old mouse cells can recover youthful cell transcriptome
See this image and copyright information in PMC

Comment on

  • Loss of epigenetic information as a cause of mammalian aging.
    Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Yang JH, et al. Cell. 2023 Jan 19;186(2):305-326.e27. doi: 10.1016/j.cell.2022.12.027. Epub 2023 Jan 12. Cell. 2023. PMID: 36638792 Free PMC article.

References

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