Validation of the imatinib-therapy failure model

Xiaoshuai Zhang^#¹, Robert Peter Gale^#², Bingcheng Liu^#³, Jian Huang^#⁴, Yanli Zhang^#⁵, Xin Du^#⁶, Jianyu Weng⁷, Weiming Li⁸, Na Xu⁹, Xiaoli Liu⁹, Chunyan Chen¹⁰, Hai Lin¹¹, Guohui Li¹², Rong Liang¹³, Zhuogang Liu¹⁴, Xiaodong Wang¹⁵, Yanqing Zhang¹⁶, Yanqiu Han¹⁷, Chunshui Liu¹⁸, Jianda Hu¹⁹, Lie Lin²⁰, Wei Yang¹⁴, Zhenfang Liu²¹, Li Meng²², Chuanqing Tu²³, Caifeng Zheng²³, Zeping Zhou²⁴, Yanliang Bai²⁵, Huiying Qiu²⁶, Suning Chen²⁶, Fei Li²⁷, Jianxin Guo²⁸, Zelin Liu²⁹, Hui Sun³⁰, Li Zhou³¹, Ru Feng³², Xiuli Sun³³, Xiaojun Huang^{34

35

36

37}, Qian Jiang^{38

39}

Affiliations

¹ Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.
² Centre for Hematology Research, Department of Immunology and Inflammation, Imperial College London, London, UK.
³ National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
⁴ Department of Hematology, he First Affiliated Hospital of Zhejiang University, College of Medicine, Zhejiang University, Department of Hematology, The Fourth Affiliated Hospital of Zhejiang University, College of Medicine, Zhejiang University, Zhejiang Provincial Clinical Research Center for Haematological Disorders, Zhejiang, China.
⁵ Henan Cancer Hospital, The Affiliate Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, China.
⁶ Division of Hematology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Guangdong, China.
⁷ Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
⁸ Union hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, China.
⁹ Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
¹⁰ Department of Hematology, Qilu Hospital of Shandong University, Jinan, China.
¹¹ Department of hematology, First Hospital of Jilin University, Jilin, China.
¹² Xi'an international medical center hospital, Shanxi, China.
¹³ Department of Hematology, Xijing Hospital, Airforce Military Medical University, Shanxi, China.
¹⁴ Shengjing Hospital of China Medical University, Shenyang, China.
¹⁵ Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
¹⁶ Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
¹⁷ The affiliated hospital of Inner Mongolia Medical University, Inner Mongolia, China.
¹⁸ Department of Hematology, Cancer Center, The First Hospital of Jilin University, Changchun, China.
¹⁹ Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fujian, China.
²⁰ Department of Hematology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
²¹ Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
²² Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
²³ Department of Hematology, Shenzhen Baoan Hospital, Shenzhen University Second Affiliated Hospital, Shenzhen, China.
²⁴ Department of Hematology, the Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China.
²⁵ Department of Hematology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
²⁶ National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Institute of Blood and Marrow Transplantation of Soochow University, Suzhou, China.
²⁷ Center of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
²⁸ Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Fujian, China.
²⁹ Department of Hematology, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen, China.
³⁰ Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
³¹ Department of Leukemia, Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³² Department of Hematology, Beijing Hospital, National Center of Gerontology, Beijing, China.
³³ Department of hematology, The first affiliated hospital of Dalian Medical University, Dalian, China.
³⁴ Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China. huangxiaojun@bjmu.edu.cn.
³⁵ Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. huangxiaojun@bjmu.edu.cn.
³⁶ Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 1, China. huangxiaojun@bjmu.edu.cn.
³⁷ Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies, Chinese Academy of Medical Sciences, Beijing, China. huangxiaojun@bjmu.edu.cn.
³⁸ Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China. jiangqian@medmail.com.cn.
³⁹ Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. jiangqian@medmail.com.cn.

^# Contributed equally.

PMID: 36973351
DOI: 10.1038/s41375-023-01875-3

Validation of the imatinib-therapy failure model

Xiaoshuai Zhang et al. Leukemia. 2023 May.

. 2023 May;37(5):1166-1169.

doi: 10.1038/s41375-023-01875-3. Epub 2023 Mar 27.

Authors

Affiliations

¹ Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.
² Centre for Hematology Research, Department of Immunology and Inflammation, Imperial College London, London, UK.
³ National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
⁴ Department of Hematology, he First Affiliated Hospital of Zhejiang University, College of Medicine, Zhejiang University, Department of Hematology, The Fourth Affiliated Hospital of Zhejiang University, College of Medicine, Zhejiang University, Zhejiang Provincial Clinical Research Center for Haematological Disorders, Zhejiang, China.
⁵ Henan Cancer Hospital, The Affiliate Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, China.
⁶ Division of Hematology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Guangdong, China.
⁷ Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
⁸ Union hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, China.
⁹ Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
¹⁰ Department of Hematology, Qilu Hospital of Shandong University, Jinan, China.
¹¹ Department of hematology, First Hospital of Jilin University, Jilin, China.
¹² Xi'an international medical center hospital, Shanxi, China.
¹³ Department of Hematology, Xijing Hospital, Airforce Military Medical University, Shanxi, China.
¹⁴ Shengjing Hospital of China Medical University, Shenyang, China.
¹⁵ Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
¹⁶ Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
¹⁷ The affiliated hospital of Inner Mongolia Medical University, Inner Mongolia, China.
¹⁸ Department of Hematology, Cancer Center, The First Hospital of Jilin University, Changchun, China.
¹⁹ Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fujian, China.
²⁰ Department of Hematology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
²¹ Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
²² Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
²³ Department of Hematology, Shenzhen Baoan Hospital, Shenzhen University Second Affiliated Hospital, Shenzhen, China.
²⁴ Department of Hematology, the Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China.
²⁵ Department of Hematology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
²⁶ National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Institute of Blood and Marrow Transplantation of Soochow University, Suzhou, China.
²⁷ Center of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
²⁸ Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Fujian, China.
²⁹ Department of Hematology, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen, China.
³⁰ Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
³¹ Department of Leukemia, Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³² Department of Hematology, Beijing Hospital, National Center of Gerontology, Beijing, China.
³³ Department of hematology, The first affiliated hospital of Dalian Medical University, Dalian, China.
³⁴ Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China. huangxiaojun@bjmu.edu.cn.
³⁵ Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. huangxiaojun@bjmu.edu.cn.
³⁶ Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 1, China. huangxiaojun@bjmu.edu.cn.
³⁷ Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies, Chinese Academy of Medical Sciences, Beijing, China. huangxiaojun@bjmu.edu.cn.
³⁸ Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China. jiangqian@medmail.com.cn.
³⁹ Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. jiangqian@medmail.com.cn.

^# Contributed equally.

PMID: 36973351
DOI: 10.1038/s41375-023-01875-3

No abstract available

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References

1. Zhang XS, Gale RP, Huang XJ, Jiang Q. Is the Sokal or EUTOS long-term survival (ELTS) score a better predictor of responses and outcomes in persons with chronic myeloid leukemia receiving tyrosine-kinase inhibitors? Leukemia. 2022;36:482–91. - DOI - PubMed
1. Hochhaus A, Baccarani M, Silver RT, Schiffer C, Apperley JF, Cervantes F, et al. European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia. Leukemia. 2020;34:966–84. - DOI - PubMed - PMC
1. Hochhaus A, Larson RA, Guilhot F, Radich JP, Branford S, Hughes TP, et al. Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia. N Engl J Med. 2017;376:917–27. - DOI - PubMed - PMC
1. Baccarani M, Deininger MW, Rosti G, Hochhaus A, Soverini S, Apperley JF, et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood. 2013;122:872–84. - DOI - PubMed - PMC
1. Guilhot J, Baccarani M, Clark RE, Cervantes F, Guilhot F, Hochhaus A, et al. Definitions, methodological and statistical issues for phase 3 clinical trials in chronic myeloid leukemia: a proposal by the European LeukemiaNet. Blood. 2012;119:5963–71. - DOI - PubMed

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Validation of the imatinib-therapy failure model

Affiliations

Validation of the imatinib-therapy failure model

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