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. 2023 Mar 28;38(1):88-94.
doi: 10.4274/MMJ.galenos.2023.29599.

Current Advances and Future Prospects in Cancer Immunotherapeutics

Zeynep Dede  1 , Kader Tumer  1 , Tugce Kan  1 , Burcu Yucel  2
Affiliations

Current Advances and Future Prospects in Cancer Immunotherapeutics

Zeynep Dede et al. Medeni Med J. .

Abstract
in English, Turkish

Cancer is a disease that results from the uncontrolled proliferation and growth of cells. Due to early detection methods, there is a decrease in death rates in many types of cancer. However, among the causes of death worldwide, cancer still ranks second after cardiovascular diseases. Therefore, cancer research has focused mainly on developing more effective treatments to reduce deaths from cancer. With a better understanding of the molecular mechanisms in cancer cells, advances in cancer treatment have evolved and changed. The main priority of research is to develop treatment modalities with the highest response rate and less side effects. In this context, immunotherapies have started a new era in cancer treatments. In this review, an overview of the future of next-generation treatment methods is presented by including the most preferred immunotherapy methods.

Kanser, hücrelerin kontrolsüz şekilde çoğalması ve büyümesi sonucu oluşan bir hastalıktır. Erken teşhis yöntemleri sayesinde birçok kanser türünde ölüm oranlarında düşüş yaşanmaktadır. Ancak tüm dünyada ölüm nedenleri arasında kanser, kardiyovasküler hastalıklardan sonra halen ikinci sıradadır. Bu nedenle, kanser araştırmalarının çoğu kanserden ölümleri azaltmak için daha etkin tedaviler geliştirmeye odaklanmıştır. Kanser hücresindeki moleküler mekanizmaların daha da iyi anlaşılmasıyla kanser tedavisindeki gelişmeler, zaman içinde gelişmiş ve değişmiştir. Araştırmaların temel önceliği en yüksek yanıt oranına ve en düşük yan etkiye sahip tedavi yöntemleri geliştirmektir. İmmünoterapiler bu bağlamda kanser tedavilerinde yeni bir dönemi başlatmıştır. Bu derlemede en çok tercih edilen immünoterapi yöntemlerine yer verilerek yeni nesil tedavi yöntemlerinin geleceğine dair genel bir bakış açısı sunulmuştur.

Keywords: CAR-T-cell therapy; Cancer; immunotherapy; mRNA vaccine; monoclonal antibody.

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Conflict of interest statement

Conflict of Interest: The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
Current advances and future prospects in cancer immunotherapies. ICI: Immune checkpoint inhibitors, mAb: Monoclonal antibody
See this image and copyright information in PMC

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