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. 2023 Mar 28;24(1):236.
doi: 10.1186/s12891-023-06362-5.

The use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers may relate to the survival and walking ability in geriatric patients with hip fractures: a 1-year follow-up study

Qining Chu  1 , Liqiang Wang  1 , Qingbo Chu  2
Affiliations

The use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers may relate to the survival and walking ability in geriatric patients with hip fractures: a 1-year follow-up study

Qining Chu et al. BMC Musculoskelet Disord. .

Abstract

Background: Many elder patients with hip fractures also suffered from hypertension. This study aims to explore the relationship between the use of ACEI or ARB and the outcomes of geriatric hip fractures.

Methods: All the patients were divided into four groups: non-users without hypertension, non-users with hypertension, ACEI users, and ARB users. The outcomes of patients in different groups were compared. LASSO regression and univariable Cox analysis were used for variable screening. Then Cox models and Logistics models were established to identify the relationships between the use of RAAS inhibitors and outcomes.

Results: ACER users (p = 0.016) and ARB users (p = 0.027) had a significantly lower survival probability than the non-users with hypertension. Non-users without hypertension, ACEI users, and ARB users may face lower 6-month and 1-year mortalities and higher 6-month and 1-year free walking rates compared with non-users with hypertension.

Conclusion: Patients with the use of ACEI or ARB may face a better prognosis of hip fractures.

Keywords: ACEI; ARB; Hip fractures; Hypertension; Prognosis.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of our study
Fig. 2
Fig. 2
Kaplan–Meier analysis of one-year survival patients grouped by the status of RAAS inhibitors using and hypertension
Fig. 3
Fig. 3
LASSO analysis for 1-year mortality and 1-year free walking rate. A The changes of coefficients with the increase of λ in LASSO models of 1-year mortality; B The changes of partial likelihood deviance with the increase of λ in LASSO models of 1-year mortality; C The changes of coefficients with the increase of λ in LASSO models of 1-year free walking rate; D The changes of AUC with the increase of λ in LASSO models of 1-year free walking rate
See this image and copyright information in PMC

References

    1. M OB. Pearse C, Zengin A, Jarjou L, Cooper C, Ebeling PR, et al. Longitudinal Change in Bone Density, Geometry, and Estimated Bone Strength in Older Men and Women From The Gambia: Findings From the Gambian Bone and Muscle Aging Study (GamBAS) J Bone Miner Res. 2023;38(1):48–58. - PMC - PubMed
    1. Tong H, Su B, Liu Z, Chen Y. Follicle-stimulating hormone and blood lead levels with bone mineral density and the risk of fractures in pre- and postmenopausal women. Front Endocrinol (Lausanne) 2022;13:1054048. - PMC - PubMed
    1. McHugh MA, Wilson JL, Schaffer NE, Olsen EC, Perdue A, Ahn J, et al. Preoperative Comorbidities Associated With Early Mortality in Hip Fracture Patients: A Multicenter Study. J Am Acad Orthop Surg. 2023;31(2):81–86. - PubMed
    1. Forssten MP, Mohammad Ismail A, Ioannidis I, Wretenberg P, Borg T, Cao Y, et al. The mortality burden of frailty in hip fracture patients: a nationwide retrospective study of cause-specific mortality. Eur J Trauma Emerg Surg. 2022. Epub ahead of print. - PMC - PubMed
    1. Liu M, Ji S, Yang C, Zhang T, Han N, Pan Y, et al. Prealbumin as a nutrition status indicator may be associated with outcomes of geriatric hip fractures: a propensity score matching and 1-year follow-up study. Aging Clin Exp Res. 2022;34(12):3005–3015. - PubMed

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