Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun 1;107(6):e178-e181.
doi: 10.1097/TP.0000000000004582. Epub 2023 May 23.

Antibody Responses Against Emerging SARS-CoV-2 Omicron Lineages After the Fourth Dose of mRNA Vaccine in Kidney Transplant Recipients

Ayman Al Jurdi  1   2 , Rodrigo B Gassen  1 , Thiago J Borges  1 , Isadora T Lape  1 , Leela Morena  1 , Frank Hullekes  1 , Orhan Efe  1   2 , Camille N Kotton  3 , Leonardo V Riella  1   2
Affiliations

Antibody Responses Against Emerging SARS-CoV-2 Omicron Lineages After the Fourth Dose of mRNA Vaccine in Kidney Transplant Recipients

Ayman Al Jurdi et al. Transplantation. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

None
Graphical abstract
FIGURE 1.
FIGURE 1.
Assessment of anti-RBD antibody levels and neutralizing responses after the fourth dose of SARS-CoV-2 monovalent mRNA vaccine in KTRs. A, IgG levels against WT SARS-CoV-2 and Omicron-lineage RBD before and after the fourth vaccine dose in KTRs (n = 25) measured by ELISA. B, As control groups, IgG levels were quantified in triple vaccinated and Omicron-infected HCs (n = 7) and in PKCs (n = 15). C, Percentage neutralization of WT and Omicron-lineage SARS-CoV-2 before and after the fourth vaccine dose in KTRs (n = 25), compared with (D) HCs (n = 7), and PKCs (n = 15) measured by surrogate virus neutralization test. E, Proportion of KTRs (n = 25) with a positive neutralization response (≥30% neutralization threshold) before and after the fourth vaccine dose. F, Neutralizing responses against WT and Omicron lineages of SARS-CoV-2 after the fourth mRNA vaccine dose in KTRs stratified by breakthrough infection status (n = 7 for breakthrough infection [BT infxn] group; n = 18 for no BT infxn group). (A, C) Statistics by Wilcoxon matched-pairs signed rank test. F, Statistics by Mann Whitney U test. HC, healthy control; KTR, kidney transplant recipient; mRNA, messenger RNA; PKC, prepandemic kidney transplant control patient; RBD, receptor-binding domain; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; WT, wild type.
See this image and copyright information in PMC

References

    1. Al Jurdi A, Gassen RB, Borges TJ, et al. . Non-invasive monitoring for rejection in kidney transplant recipients after SARS-CoV-2 mRNA vaccination. Front Immunol. 2022;13:838985. - PMC - PubMed
    1. Al Jurdi A, Gassen RB, Borges TJ, et al. . Suboptimal antibody response against SARS-CoV-2 Omicron variant after third dose of mRNA vaccine in kidney transplant recipients. Kidney Int. 2022;101:1282–1286. - PMC - PubMed
    1. Tan CW, Chia WN, Qin X, et al. . A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction. Nat Biotechnol. 2020;38:1073–1078. - PubMed
    1. Davis-Gardner ME, Lai L, Wali B, et al. . Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent Booster. N Engl J Med. 2023;388:183–185. - PMC - PubMed