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. 2023 Feb 26;13(3):406.
doi: 10.3390/brainsci13030406.

Executive Profile of the Logopenic Variant of Primary Progressive Aphasia: Comparison with the Semantic and Non-Fluent Variants and Alzheimer's Disease

Sandrine Basaglia-Pappas  1   2 , Bernard Laurent  1 , Jean-Claude Getenet  1 , Anne Boulangé  1 , Aurelia Rendón de laCruz  2 , Isabelle Simoes Loureiro  2 , Laurent Lefebvre  2
Affiliations

Executive Profile of the Logopenic Variant of Primary Progressive Aphasia: Comparison with the Semantic and Non-Fluent Variants and Alzheimer's Disease

Sandrine Basaglia-Pappas et al. Brain Sci. .

Abstract

The logopenic variant of primary progressive aphasia (lvPPA) shows different features from the non-fluent (nfvPPA) and semantic (svPPA) variants of PPA. Although language impairments remain the core symptoms, studies have highlighted the presence of executive disorders at the onset of the disease. Nevertheless, the results are contradictory, particularly in lvPPA. The aim of this study was to explore the executive profile of lvPPA. We compared executive functioning in lvPPA with the other two variants of PPA, Alzheimer's disease (AD) and a cognitively healthy group. In total, 70 patients with PPA, 32 patients with AD, and 41 healthy controls were included. They underwent a comprehensive executive battery assessing short-term and working memory, inhibition, flexibility, planning, and initiation. The analyses showed significant differences between the lvPPA group and the control group, except on visuospatial spans and the Stroop test, and between the lvPPA group and the other PPA groups and the AD group for several tasks. Thus, this research highlighted the existence of an executive dysfunction from the onset of the disease in lvPPA but also in the other two variants of PPA.

Keywords: Alzheimer’s disease; assessment; diagnosis; executive functions; primary progressive aphasia.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Executive tasks showing statistically significant differences between lvPPA and other clinical groups, inspired by Matias-Guiu et al. [36].
See this image and copyright information in PMC

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