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. 2023 Feb 21;13(3):401.
doi: 10.3390/biom13030401.

Role of Altered Metabolism of Triglyceride-Rich Lipoprotein Particles in the Development of Vascular Dysfunction in Systemic Lupus Erythematosus

Ágnes Diószegi  1 , Hajnalka Lőrincz  1 , Eszter Kaáli  2 , Pál Soltész  3 , Bianka Perge  4 , Éva Varga  5 , Mariann Harangi  1   6 , Tünde Tarr  4
Affiliations

Role of Altered Metabolism of Triglyceride-Rich Lipoprotein Particles in the Development of Vascular Dysfunction in Systemic Lupus Erythematosus

Ágnes Diószegi et al. Biomolecules. .

Abstract

Background: Impaired lipid metabolism contributes to accelerated inflammatory responses in addition to promoting the formation of atherosclerosis in systemic lupus erythematosus (SLE). We aimed to evaluate the lipid profile, inflammatory markers, and vascular diagnostic tests in active SLE patients to clarify the association between dyslipidemia and early vascular damage.

Patients and methods: 51 clinically active SLE patients and 41 age- and gender-matched control subjects were enrolled in the study. Lipoprotein subfractions were detected by Lipoprint. Brachial artery flow-mediated dilation and common carotid intima-media thickness were detected by ultrasonography. Arterial stiffness indicated by augmentation index (Aix) and pulse wave velocity was measured by arteriography.

Results: We found significantly higher Aix, higher VLDL ratio, plasma triglyceride, ApoB100, and small HDL, as well as lower HDL-C, large HDL, and ApoA1 in patients with SLE. There was a significant positive correlation of Aix with triglyceride, VLDL, IDL-C, IDL-B, and LDL1. A backward stepwise multiple regression analysis showed IDL-C subfraction to be the best predictor of Aix.

Conclusions: Our results indicate that in young patients with SLE, triglyceride-rich lipoproteins influence vascular function detected by Aix. These parameters may be assessed and integrated into the management plan for screening cardiovascular risk in patients with SLE.

Keywords: augmentation index; carotid intima-media thickness; flow-mediated dilation; intermediate-density lipoprotein; systemic lupus erythematosus; triglyceride; triglyceride-rich lipoproteins; very low-density lipoprotein.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Correlations between levels of very low-density lipoprotein (VLDL) (a), intermediate density lipoprotein (IDL-C) (b), IDL-B (c), low-density lipoprotein-1 (LDL1) (d) subfractions and augmentation index (Aix) in patients with systemic lupus erythematosus (SLE).
Figure 2
Figure 2
Correlations between high-sensitivity C-reactive protein (hsCRP) (a), triglyceride (TG) (b), low-density lipoprotein cholesterol (LDL-C) (c), apolipoprotein B (ApoB) (d), very low-density lipoprotein (VLDL) subfraction (e), LDL2 subfraction (f) and flow-mediated dilation (FMD) in patients with systemic lupus erythematosus (SLE).
Figure 3
Figure 3
Correlations between complement factor 4 (C4) and carotid intima media thickness (IMT) (a) in patients with systemic lupus erythematosus (SLE). C4 (b), apolipoprotein B (ApoB) (c) and IMT (d) in patients with mild/moderate SLE disease activity (SLEDAI = 0–10) and with high/very high SLEDAI (SLEDAI < 11).
See this image and copyright information in PMC

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