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Review
. 2023 Mar 2;13(3):465.
doi: 10.3390/biom13030465.

CAR-T Cells in the Treatment of Ovarian Cancer: A Promising Cell Therapy

Xi-Wen Zhang  1 , Yi-Shi Wu  1 , Tian-Min Xu  1 , Man-Hua Cui  1
Affiliations
Review

CAR-T Cells in the Treatment of Ovarian Cancer: A Promising Cell Therapy

Xi-Wen Zhang et al. Biomolecules. .

Abstract

Ovarian cancer (OC) is among the most common gynecologic malignancies with a poor prognosis and a high mortality rate. Most patients are diagnosed at an advanced stage (stage III or IV), with 5-year survival rates ranging from 25% to 47% worldwide. Surgical resection and first-line chemotherapy are the main treatment modalities for OC. However, patients usually relapse within a few years of initial treatment due to resistance to chemotherapy. Cell-based therapies, particularly adoptive T-cell therapy and chimeric antigen receptor T (CAR-T) cell therapy, represent an alternative immunotherapy approach with great potential for hematologic malignancies. However, the use of CAR-T-cell therapy for the treatment of OC is still associated with several difficulties. In this review, we comprehensively discuss recent innovations in CAR-T-cell engineering to improve clinical efficacy, as well as strategies to overcome the limitations of CAR-T-cell therapy in OC.

Keywords: CAR; CAR-T; immunotherapy; ovarian cancer.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of allogeneic CAR-T-cell production.
Figure 2
Figure 2
Antigenic targets of OC cells and related functions of CAR-T cells targeting these tumor antigens.
Figure 3
Figure 3
The challenges for CAR-T-cell therapy for the treatment of OC.
Figure 4
Figure 4
Mechanisms of tumor immune escape.
Figure 5
Figure 5
Different types of CAR-T cells are designed to inhibit immune escape.
Figure 6
Figure 6
Schematic diagram of six methods to improve the therapeutic effect of CAR-T-cell therapy.
Figure 7
Figure 7
Ways to improve CAR-T-cell therapy.
Figure 8
Figure 8
Mechanism of chemotherapy to improve the effect of CAR-T therapy.
Figure 9
Figure 9
Mechanism diagram of radiotherapy to enhance the therapeutic effect of CAR-T-cell therapy.
See this image and copyright information in PMC

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