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. 2023 Mar 16;10(3):567.
doi: 10.3390/children10030567.

Hematologic Risk Factors for the Development of Retinopathy of Prematurity-A Retrospective Study

Gabriela Ildiko Zonda  1 , Raluca Mogos  1 , Alina-Sînziana Melinte-Popescu  2 , Ana-Maria Adam  3 , Valeriu Harabor  3 , Dragos Nemescu  1 , Demetra Socolov  1 , Anamaria Harabor  3 , Marian Melinte-Popescu  4 , Maura Adelina Hincu  1 , Ingrid-Andrada Vasilache  1 , Alexandru Carauleanu  1 , Gigi Adam  5 , Luminita Paduraru  1
Affiliations

Hematologic Risk Factors for the Development of Retinopathy of Prematurity-A Retrospective Study

Gabriela Ildiko Zonda et al. Children (Basel). .

Abstract

(1) Background: Retinopathy of prematurity (ROP) can cause severe visual impairment or even blindness. We aimed to assess the hematological risk factors that are associated with different stages of ROP in a cohort of preterm newborns, and to compare the clinical characteristics and therapeutic interventions between groups. (2) Methods: This retrospective study included 149 preterm newborns from a tertiary maternity hospital in Romania between January 2018 and December 2018, who were segregated into: Group 1 (with ROP, n = 59 patients), and Group 2 (without ROP, n = 90 patients). The patients that were affected by ROP were subsequently divided into the following subgroups: Subgroup 1 (Stage 1, n = 21), Subgroup 2 (Stage 2, n = 35), and Subgroup 3 (Stage 3, n = 25). The associations were analyzed using multivariate logistic regression and sensitivity analysis. (3) Results: Platelet mass indexes (PMI) that were determined in the first, seventh, and tenth days of life were significantly associated with Stage 1 ROP. PMI determined in the first day of life was also significantly associated with Stage 2 ROP. The sensitivity and specificity of these parameters were modest, ranging from 44 to 57%, and 59 to 63%. (4) Conclusions: PMI has a modest ability to predict the development of ROP.

Keywords: hematological parameters; platelet mass index; retinopathy of prematurity; risk factor identification.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
ROC curve of PMI determined in the first day of life for the prediction of Stage 1 ROP. Legend: ROC—receiver operating characteristic; PMI—platelet mass index; ROP—retinopathy of prematurity.
Figure 2
Figure 2
ROC curve of PMI determined in the seventh day of life for the prediction of Stage 1 ROP. Legend: ROC—teceiver operating characteristic; PMI—platelet mass index; ROP—retinopathy of prematurity.
Figure 3
Figure 3
ROC curve of PMI determined in the tenth day of life for the prediction of Stage 1 ROP. Legend: ROC—receiver operating characteristic; PMI—platelet mass index; ROP—retinopathy of prematurity.
Figure 4
Figure 4
ROC curve of PMI determined in the first day of life for the prediction of Stage 2 ROP. Legend: ROC—receiver operating characteristic; PMI—platelet mass index; ROP—retinopathy of prematurity.
See this image and copyright information in PMC

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