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. 1986 Mar;19(2):155-60.
doi: 10.1111/j.1365-2184.1986.tb00725.x.

Urothelial proliferation in growing mice

S P Jost, C S Potten

Urothelial proliferation in growing mice

S P Jost et al. Cell Tissue Kinet. 1986 Mar.

Abstract

Developing murine urothelium undergoes pronounced proliferation until at least 10 days after birth. Thereafter, both mitotic and [3H]TdR-labelling indices fall sharply with age. The ratio of labelling to mitotic indices also alters dramatically during development, which is probably due to both endoreduplication and changes in the relative durations of the DNA synthesis and mitotic phases. This ratio reaches stability at 5 weeks of age. The adult labelling and mitotic indices were 0.11 and 0.019% respectively, indicating a very slow turnover.

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