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. 2023 Mar 11;20(6):4951.
doi: 10.3390/ijerph20064951.

The Effect of Serum Leptin Concentration and Leptin Receptor Expression on Colorectal Cancer

Sylwia Chludzińska-Kasperuk  1   2 , Jolanta Lewko  2 , Regina Sierżantowicz  3 , Elżbieta Krajewska-Kułak  4 , Joanna Reszeć-Giełażyn  5
Affiliations

The Effect of Serum Leptin Concentration and Leptin Receptor Expression on Colorectal Cancer

Sylwia Chludzińska-Kasperuk et al. Int J Environ Res Public Health. .

Abstract

Introduction: The level of leptin in the blood shows a positive, strong correlation with the mass of adipose tissue. Being overweight and having metabolic disorders increase the risk of developing colorectal cancer.

Aim of the paper: The aim of the study was to assess the concentration of leptin in the blood serum as well as the expression of the leptin receptor in colorectal cancer cells. In addition, the effect of serum leptin concentration and leptin receptor expression on clinical and pathological parameters such as BMI, obesity, TNM, and tumor size was assessed.

Methods: The study included 61 patients diagnosed with colorectal cancer and treated with surgery.

Results: Strong leptin receptor expression and the prevalence of overweight and obesity are factors influencing the occurrence of excessive leptin concentrations.

Conclusion: Leptin may be involved in the development and progression of colorectal cancer. More research is needed to better elucidate the role of leptin in the development and progression of the disease.

Keywords: colorectal cancer; leptin; leptin receptor expression; obesity.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Leptin receptor expression among patients in the study group (n = 61) and comparison group (n = 20). Statistical analysis was performed using the Kruskal-Wallis test and the Mann-Whitney test; * p = 0.001, CI (confidence interval) was calculated by Student’s t-test.
Figure 2
Figure 2
Median values with lower and upper quartiles and minimum and a maximum leptin concentrations for both sexes relative to prescription leptin expression (N = 61). Statistical analysis was performed using the Kruskal-Wallis test and the Mann-Whitney test; p-value < 0.05, * p = 0.0032.
Figure 3
Figure 3
Spearman’s rank correlation between age and leptin concentration among patients in the study group (male: n = 39; female: n = 22).
Figure 4
Figure 4
Spearman’ rank correlation between BMI and serum leptin concentration among patients in the study group (male: n = 39; female: n = 22).
Figure 5
Figure 5
Comparison of leptin concentration in the study and comparison groups. Study group (n = 61); control group (n = 60). Statistical analysis was performed using the Kruskal-Wallis test and the Mann-Whitney test; p-value < 0.05.
Figure 6
Figure 6
Relationship between BMI and leptin concentration in logarithmic form in the study and comparative group separately for females and males. Study group: female (n = 22); male (n = 39). Control group: female (n = 33); male (n = 27).
See this image and copyright information in PMC

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