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Review
. 2023 Mar 7;24(6):5072.
doi: 10.3390/ijms24065072.

The Role of Citicoline and Coenzyme Q10 in Retinal Pathology

Claudia García-López  1 , Verónica García-López  1 , José A Matamoros  1   2 , José A Fernández-Albarral  1 , Elena Salobrar-García  1   2 , Rosa de Hoz  1   2 , Inés López-Cuenca  1 , Lidia Sánchez-Puebla  1 , José M Ramírez  1   3 , Ana I Ramírez  1   2 , Juan J Salazar  1   2
Affiliations
Review

The Role of Citicoline and Coenzyme Q10 in Retinal Pathology

Claudia García-López et al. Int J Mol Sci. .

Abstract

Ocular neurodegenerative diseases such as glaucoma, diabetic retinopathy, and age-related macular degeneration are common retinal diseases responsible for most of the blindness causes in the working-age and elderly populations in developed countries. Many of the current treatments used in these pathologies fail to stop or slow the progression of the disease. Therefore, other types of treatments with neuroprotective characteristics may be necessary to allow a more satisfactory management of the disease. Citicoline and coenzyme Q10 are molecules that have neuroprotective, antioxidant, and anti-inflammatory properties, and their use could have a beneficial effect in ocular neurodegenerative pathologies. This review provides a compilation, mainly from the last 10 years, of the main studies that have been published on the use of these drugs in these neurodegenerative diseases of the retina, analyzing the usefulness of these drugs in these pathologies.

Keywords: CoQ10; age-related macular degeneration; citicoline; coenzyme Q10; diabetic retinopathy; eye; glaucoma; non-arteritic ischemic optic neuropathy; retina.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic summary of the main ocular benefits of citicoline and CoQ10 in different ocular pathologies (created in part with smart.servier.com). ERG: electroretinogram; mfERG: multifocal electroretinogram; pERG: pattern electroretinogram; RGC: retinal ganglion cell; ROS: reactive oxygen spices; RNFL: retinal nerve fiber layer; VEGF: vascular endothelial growth factor ; VEP: visual evoked potential.
See this image and copyright information in PMC

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