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. 2023 Mar 7;12(6):2092.
doi: 10.3390/jcm12062092.

Value of Right and Left Ventricular T1 and T2 Blood Pool Mapping in Patients with Chronic Thromboembolic Hypertension before and after Balloon Pulmonary Angioplasty

Fritz C Roller  1   2 , Armin Schüßler  1   2 , Nils Kremer  2   3 , Sebastian Harth  1   2 , Steffen D Kriechbaum  4   5 , Christoph B Wiedenroth  6 , Stefan Guth  6 , Andreas Breithecker  7 , Manuel Richter  2   3 , Khodr Tello  2   3 , Werner Seeger  2   3 , Eckhard Mayer  6 , Gabriele A Krombach  1   2
Affiliations

Value of Right and Left Ventricular T1 and T2 Blood Pool Mapping in Patients with Chronic Thromboembolic Hypertension before and after Balloon Pulmonary Angioplasty

Fritz C Roller et al. J Clin Med. .

Abstract

Background: Parametric imaging has taken a steep rise in recent years and non-cardiac applications are of increasing interest. Therefore, the aim of our study was to assess right (RV) and left ventricular (LV) blood pool T1 and T2 values in patients with chronic thromboembolic pulmonary hypertension (CTEPH) compared to control subjects and their correlation to pulmonary hemodynamic.

Methods: 26 patients with CTEPH (mean age 64.8 years ± 12.8 SD; 15 female), who underwent CMR and right heart catheterization (RHC) before and 6-months after balloon pulmonary angioplasty (BPA), were retrospectively included. Ventricular blood pool values were measured, compared to control subjects (mean age 40.5 years ± 12.8 SD; 16 female) and correlated to invasive measures (CI, mPAP, PVR).

Results: In both, control subjects and CTEPH patients, RVT1 and RVT2 were significantly reduced compared to LVT1 and LVT2. Compared to control subjects, RVT2 was significantly reduced in CTEPH patients (p = 0.0065) and increased significantly after BPA (p = 0.0048). Moreover, RVT2 was positively correlated with CI and negatively correlated with mPAP and PVR before (r = 0.5155, r = -0.2541, r = -0.4571) and after BPA (r = 0.4769, r = -0.2585, r = -0.4396).

Conclusion: Ventricular blood pool T2 mapping might be novel non-invasive CMR imaging marker for assessment of disease severity, prognosis, follow-up and even therapy monitoring in PH.

Keywords: CMR; CTEPH; T1 mapping; T2 mapping; parametric imaging.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Figure shows the native T1 Map (A) and T2 Map (B) of a control subject and the native T1 Map (C) and T2 Map (D) of a CTEPH patient at basal short axis sections. The color-bar-scales on the left side presents the different T1 and T2 values from low to high.
Figure 2
Figure 2
Figure shows the pre- (A) and postprocedural (B) T2 Map of a 53-year old male CTEPH patient at basal short axis section. T2 measurements were performed in regions-of-interest (black circles) for the left (LV) and right ventricular (RV) blood pool. The LVT2 and RVT2 values before BPA were 211 ms and 153 ms and after BPA 268 ms and 228 ms. Furthermore, a decreasing flattening of the interventricular septum is seen in the course of the BPA therapy. The color-bar-scale on the left side presents the different T2 values from low to high.
See this image and copyright information in PMC

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