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. 2023 Mar 10;12(6):2172.
doi: 10.3390/jcm12062172.

Trends in Net Survival from Vulvar Squamous Cell Carcinoma in Italy (1990-2015)

Silvia Mancini  1 , Lauro Bucchi  1 , Federica Zamagni  1 , Flavia Baldacchini  1 , Emanuele Crocetti  1 , Orietta Giuliani  1 , Alessandra Ravaioli  1 , Rosa Vattiato  1 , Mario Preti  2 , Rosario Tumino  3 , Stefano Ferretti  4 , Annibale Biggeri  5 , Paola Ballotari  6 , Lorenza Boschetti  7 , Angelita Brustolin  8 , Adele Caldarella  9 , Rossella Cavallo  10 , Claudia Cirilli  11 , Annarita Citarella  12 , Maria L Contrino  13 , Luigino Dal Maso  14 , Rosa A Filiberti  15 , Mario Fusco  16 , Rocco Galasso  17 , Fernanda L Lotti  18 , Michele Magoni  19 , Lucia Mangone  20 , Giuseppe Masanotti  21 , Guido Mazzoleni  22 , Walter Mazzucco  23 , Anna Melcarne  24 , Maria Michiara  25 , Paola Pesce  26 , Angela Pinto  27 , Daniela Piras  28 , Roberto V Rizzello  29 , Magda Rognoni  30 , Stefano Rosso  31 , Massimo Rugge  32 , Giuseppe Sampietro  33 , Santo Scalzi  34 , Tiziana Scuderi  35 , Giovanna Tagliabue  36 , Federica Toffolutti  14 , Susanna Vitarelli  37 , Fabio Falcini  1   38 ; AIRTUM Working Group
Affiliations

Trends in Net Survival from Vulvar Squamous Cell Carcinoma in Italy (1990-2015)

Silvia Mancini et al. J Clin Med. .

Abstract

(1) Objective: In many Western countries, survival from vulvar squamous cell carcinoma (VSCC) has been stagnating for decades or has increased insufficiently from a clinical perspective. In Italy, previous studies on cancer survival have not taken vulvar cancer into consideration or have pooled patients with vulvar and vaginal cancer. To bridge this knowledge gap, we report the trend in survival from vulvar cancer between 1990 and 2015. (2) Methods: Thirty-eight local cancer registries covering 49% of the national female population contributed the records of 6274 patients. Study endpoints included 1- and 2-year net survival (NS) calculated using the Pohar-Perme estimator and 5-year NS conditional on having survived two years (5|2-year CNS). The significance of survival trends was assessed with the Wald test on the coefficient of the period of diagnosis, entered as a continuous regressor in a Poisson regression model. (3) Results: The median patient age was stable at 76 years. One-year NS decreased from 83.9% in 1990-2001 to 81.9% in 2009-2015 and 2-year NS from 72.2% to 70.5%. Five|2-year CNS increased from 85.7% to 86.7%. These trends were not significant. In the age stratum 70-79 years, a weakly significant decrease in 2-year NS from 71.4% to 65.7% occurred. Multivariate analysis adjusting for age group at diagnosis and geographic area showed an excess risk of death at 5|2-years, of borderline significance, in 2003-2015 versus 1990-2002. (4) Conclusions: One- and 2-year NS and 5|2-year CNS showed no improvements. Current strategies for VSCC control need to be revised both in Italy and at the global level.

Keywords: survival; trend; vulvar neoplasms.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Geographic distribution of the 38 cancer registries participating in the study on time trends in net survival from vulvar squamous cell carcinoma in Italy between 1990 and 2015 (total resident female population 15,358,161 in 2015).
Figure 2
Figure 2
Trends in total 1- and 2-year net survival and in 5|2-year conditional net survival from vulvar squamous cell carcinoma in Italy between 1990 and 2015 (total resident female population 15,358,161 in 2015).
Figure 3
Figure 3
Trends in total 1- and 2-year net survival and in 5|2-year conditional net survival from vulvar squamous cell carcinoma in Italy between 1990 and 2015 among patients aged <60 (i.e., 15–59) years (A) and <50 (i.e., 15–49) years (B) (total resident female population 10,715,318 aged <60 years and 8,537,374 aged <50 years in 2015).
See this image and copyright information in PMC

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