Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Mar 14;12(6):2235.
doi: 10.3390/jcm12062235.

One-Year Review in Cardiac Arrest: The 2022 Randomized Controlled Trials

Alessio Penna  1   2 , Aurora Magliocca  1   3 , Giulia Merigo  2 , Giuseppe Stirparo  4 , Ivan Silvestri  1   2 , Francesca Fumagalli  3 , Giuseppe Ristagno  1   2
Affiliations
Review

One-Year Review in Cardiac Arrest: The 2022 Randomized Controlled Trials

Alessio Penna et al. J Clin Med. .

Abstract

Cardiac arrest, one of the leading causes of death, accounts for numerous clinical studies published each year. This review summarizes the findings of all the randomized controlled clinical trials (RCT) on cardiac arrest published in the year 2022. The RCTs are presented according to the following categories: out-of- and in-hospital cardiac arrest (OHCA, IHCA) and post-cardiac arrest care. Interestingly, more than 80% of the RCTs encompassed advanced life support and post-cardiac arrest care, while no studies focused on the treatment of IHCA, except for one that, however, explored the temperature control after resuscitation in this population. Surprisingly, 9 out of 11 RCTs led to neutral results demonstrating equivalency between the newly tested interventions compared to current practice. One trial was negative, showing that oxygen titration in the immediate pre-hospital post-resuscitation period decreased survival compared to a more liberal approach. One RCT was positive and introduced new defibrillation strategies for refractory cardiac arrest. Overall, data from the 2022 RCTs discussed here provide a solid basis to generate new hypotheses to be tested in future clinical studies.

Keywords: cardiac arrest; cardiopulmonary resuscitation; outcome; randomized controlled trial.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 3
Figure 3
Word cloud of the 50 most common terms present in the 11 randomized clinical trials included in the review.
Figure 4
Figure 4
Number of randomized clinical trials published in 2022 for each link of the chain of survival [4,9,15,17,22,30,38,45,51,52,60,63,65].
Figure 1
Figure 1
Studies on cardiac arrest published in the last 60 years, with a focus on the last ten years.
Figure 2
Figure 2
Diagram flow of article selection for inclusion in the review.
See this image and copyright information in PMC

References

    1. Gräsner J.T., Herlitz J., Tjelmeland I.B.M., Wnent J., Masterson S., Lilja G., Bein B., Böttiger B.W., Rosell-Ortiz F., Nolan J.P., et al. European Resuscitation Council Guidelines 2021: Epidemiology of cardiac arrest in Europe. Resuscitation. 2021;161:61–79. doi: 10.1016/j.resuscitation.2021.02.007. - DOI - PubMed
    1. Semeraro F., Greif R., Böttiger B.W., Burkart R., Cimpoesu D., Georgiou M., Yeung J., Lippert F., Lockey A.S., Olasveengen T.M., et al. European Resuscitation Council Guidelines 2021: Systems saving lives. Resuscitation. 2021;161:80–97. doi: 10.1016/j.resuscitation.2021.02.008. - DOI - PubMed
    1. Yannopoulos D., Bartos J., Raveendran G., Walser E., Connett J., Murray T.A., Collins G., Zhang L., Kalra R., Kosmopoulos M., et al. Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): A phase 2, single centre, open-label, randomised controlled trial. Lancet. 2020;396:1807–1816. doi: 10.1016/S0140-6736(20)32338-2. - DOI - PMC - PubMed
    1. Belohlavek J., Smalcova J., Rob D., Franek O., Smid O., Pokorna M., Horák J., Mrazek V., Kovarnik T., Zemanek D., et al. Prague OHCA Study Group. Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA. 2022;327:737–747. doi: 10.1001/jama.2022.1025. - DOI - PMC - PubMed
    1. Gräsner J.T., Wnent J., Herlitz J., Perkins G.D., Lefering R., Tjelmeland I., Koster R.W., Masterson S., Rossell-Ortiz F., Maurer H., et al. Survival after out-of-hospital cardiac arrest in Europe—Results of the EuReCa TWO study. Resuscitation. 2020;148:218–226. doi: 10.1016/j.resuscitation.2019.12.042. - DOI - PubMed