PET Criteria by Cancer Type from Imaging Interpretation to Treatment Response Assessment: Beyond FDG PET Score

Francesco Dondi¹, Achille Lazzarato², Joana Gorica³, Priscilla Guglielmo⁴, Francesca Borgia⁵, Rossella Filice⁶, Antonio Vento⁷, Sara Pacella⁸, Riccardo Camedda⁹, Matteo Caracciolo⁵, Maria Silvia De Feo³, Paolo Mammucci¹⁰, Viviana Frantellizzi³, Naima Ortolan⁵, Elisa Fiasconaro¹¹, Luca Urso⁵, Laura Evangelista¹², Riccardo Laudicella^{11

13}, Giulia Santo¹⁴; Young Italian Association of Nuclear Medicine (AIMN) Working Group

Affiliations

¹ Nuclear Medicine, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
² Unit of Nuclear Medicine, Department of Medicine, Surgery and Pharmacy, Università degli Studi di Sassari, 07100 Sassari, Italy.
³ Department of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza, University of Rome, 00161 Rome, Italy.
⁴ Nuclear Medicine Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
⁵ Nuclear Medicine Unit, Oncological Medical and Specialists Department, University Hospital of Ferrara, 44124 Ferrara, Italy.
⁶ Nuclear Medicine Unit, University Hospital "Paolo Giaccone", Via del Vespro 129, 90127 Palermo, Italy.
⁷ Nuclear Medicine Department, ASP 1-P.O. San Giovanni di Dio, 92100 Agrigento, Italy.
⁸ Nuclear Medicine Department, Fondazione IRCCS Ca'Granda, Ospedale Maggiore Policlinico, via Francesco Sforza 35, 20122 Milan, Italy.
⁹ Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.
¹⁰ Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy.
¹¹ Nuclear Medicine Unit, S. Antonio Abate Hospital, 54027 Trapani, Italy.
¹² Department of Medicine DIMED, University of Padua, 35128 Padua, Italy.
¹³ Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, University of Messina, 98125 Messina, Italy.
¹⁴ Department of Experimental and Clinical Medicine, "Magna Graecia" University of Catanzaro, 88100 Catanzaro, Italy.

PMID: 36983767
PMCID: PMC10057339
DOI: 10.3390/life13030611

Review

PET Criteria by Cancer Type from Imaging Interpretation to Treatment Response Assessment: Beyond FDG PET Score

Francesco Dondi et al. Life (Basel). 2023.

. 2023 Feb 22;13(3):611.

doi: 10.3390/life13030611.

Authors

Affiliations

¹ Nuclear Medicine, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
² Unit of Nuclear Medicine, Department of Medicine, Surgery and Pharmacy, Università degli Studi di Sassari, 07100 Sassari, Italy.
³ Department of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza, University of Rome, 00161 Rome, Italy.
⁴ Nuclear Medicine Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
⁵ Nuclear Medicine Unit, Oncological Medical and Specialists Department, University Hospital of Ferrara, 44124 Ferrara, Italy.
⁶ Nuclear Medicine Unit, University Hospital "Paolo Giaccone", Via del Vespro 129, 90127 Palermo, Italy.
⁷ Nuclear Medicine Department, ASP 1-P.O. San Giovanni di Dio, 92100 Agrigento, Italy.
⁸ Nuclear Medicine Department, Fondazione IRCCS Ca'Granda, Ospedale Maggiore Policlinico, via Francesco Sforza 35, 20122 Milan, Italy.
⁹ Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.
¹⁰ Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy.
¹¹ Nuclear Medicine Unit, S. Antonio Abate Hospital, 54027 Trapani, Italy.
¹² Department of Medicine DIMED, University of Padua, 35128 Padua, Italy.
¹³ Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, University of Messina, 98125 Messina, Italy.
¹⁴ Department of Experimental and Clinical Medicine, "Magna Graecia" University of Catanzaro, 88100 Catanzaro, Italy.

PMID: 36983767
PMCID: PMC10057339
DOI: 10.3390/life13030611

Abstract

Background: in recent years, the role of positron emission tomography (PET) and PET/computed tomography (PET/CT) has emerged as a reliable diagnostic tool in a wide variety of pathological conditions. This review aims to collect and review PET criteria developed for interpretation and treatment response assessment in cases of non-[¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) imaging in oncology.

Methods: A wide literature search of the PubMed/MEDLINE, Scopus and Google Scholar databases was made to find relevant published articles about non-[¹⁸F]FDG PET response criteria.

Results: The comprehensive computer literature search revealed 183 articles. On reviewing the titles and abstracts, 149 articles were excluded because the reported data were not within the field of interest. Finally, 34 articles were selected and retrieved in full-text versions.

Conclusions: available criteria are a promising tool for the interpretation of non-FDG PET scans, but also to assess the response to therapy and therefore to predict the prognosis. However, oriented clinical trials are needed to clearly evaluate their impact on patient management.

Keywords: FuMeGa; NAFCIST; NETPET; PPP; PRIMARY; PSMA-RADS; Pro-PET; RECIP 1.0; SSTR-RADS; miTNM; non-FDG PET criteria.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
PRISMA flowchart of research strategy and studies selection.

**Figure 2**
The fifteen non-[¹⁸F]FDG PET criteria retrieved from literature research and categorized following different tissues.

See this image and copyright information in PMC

References

1. Basu S., Hess S., Nielsen Braad P.E., Olsen B.B., Inglev S., Høilund-Carlsen P.F. The Basic Principles of FDG-PET/CT Imaging. PET Clin. 2014;9:355–370. doi: 10.1016/j.cpet.2014.07.006. - DOI - PubMed
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1. Annovazzi A., Vari S., Giannarelli D., Pasqualoni R., Sciuto R., Carpano S., Cognetti F., Ferraresi V. Comparison of 18F-FDG PET/CT Criteria for the Prediction of Therapy Response and Clinical Outcome in Patients With Metastatic Melanoma Treated With Ipilimumab and PD-1 Inhibitors. Clin. Nucl. Med. 2020;45:187–194. doi: 10.1097/RLU.0000000000002921. - DOI - PubMed

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PET Criteria by Cancer Type from Imaging Interpretation to Treatment Response Assessment: Beyond FDG PET Score

Affiliations

PET Criteria by Cancer Type from Imaging Interpretation to Treatment Response Assessment: Beyond FDG PET Score

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

LinkOut - more resources

Full Text Sources

Miscellaneous