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. 2023 Mar 15;13(3):789.
doi: 10.3390/life13030789.

Bovine Grafting: An Effective Alternative after Curettage of Benign Bone Tumors

Priscilla Montanhini  1   2 , Bruno P Antunes  1   2 , Julie Francine Cerutti Pestilho  3 , Carlos Roberto Galia  1   2 , Alex Guedes  4 , Ricardo Gehrke Becker  1   2   3
Affiliations

Bovine Grafting: An Effective Alternative after Curettage of Benign Bone Tumors

Priscilla Montanhini et al. Life (Basel). .

Abstract

We retrospectively reviewed 28 patients (15 women and 13 men) with benign bone tumors or pseudotumors treated with curettage and filling with freeze-dried bovine bone graft Orthogen (Baumer S/A, São Paulo, Brazil). The aim of the study was to evaluate the rate of incorporation of Orthogen into the host bone, as well as to describe the outcomes of bone healing (quality, time, and complications). General characteristics, tumor volume, size, site, complications, percent filled, and healing quality at 6 and 12 months were assessed through radiographs. Mean patient age was 20.5 (range 4.7-75.1) years. The most common lesion type was simple bone cyst (12/28), and the most common sites were the tibia (7/28) and humerus (7/28). There were no postoperative pathologic fractures. Two cases (7.1%) of serous fluid leakage through the wound occurred. Mean cavity volume was 20.1 (range 2.7-101.4) cm3. At 6 and 12 months, 75% and 77.8% of cavities, respectively, showed complete bone healing. At 12 months, 81% of cavities filled >90% with graft showed complete bone healing vs. only 19% of those filled <90%. Filling with bovine bone graft resulted in few complications and excellent healing after curettage of benign bone tumors or pseudotumors. Complete healing occurred in most cases by 12 months. Cavities with a higher percentage of filling had a higher rate of complete radiographic incorporation.

Keywords: biocompatible materials; bone cysts; bone grafting; bone neoplasms; bone substitute; xenografts.

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Conflict of interest statement

The authors declare that this study received funding from Baumer S.A., São Paulo, Brazil. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.

Figures

Figure 1
Figure 1
(A,B) Preoperative radiograph, anteroposterior, and lateral views. Volume measurement in a unicameral bone cyst of the proximal femur. Application of the volume formula ABC × 0.785 = 52.25 cm3 (cylindrical defect). (C) Immediate postoperative radiograph after curettage, grafting, and plate fixation. Bone graft homogeneously distributed in the cavity with >90% filling. (D) Postoperative 6-month follow-up radiograph showing cortical thickening and partial graft incorporation. (E,F) Radiographs at 12- and 24-month follow-up, showing complete graft incorporation (Neer I) and bone remodeling.
Figure 2
Figure 2
(A) Preoperative radiograph of a unicameral bone cyst of the humerus. (B) Immediate postoperative radiograph after curettage and bone graft filling <90% of the cavity. (C,D) Postoperative 6- and 12-month follow-up radiographs showing radiolucent area <50% (arrow) of the bone diameter (Neer II). (E) Twenty-four-month follow-up radiograph showing cortical thickening, bone remodeling, and small intramedullary cystic remnants.
Figure 3
Figure 3
(A) Preoperative radiograph of a nonossifying fibroma of the distal femur. (B) Immediate postoperative radiograph after curettage showing poor cavity filling with bone graft. Dashed lines delimit the grafted area. (C) Postoperative 6-month follow-up radiograph showing persistent radiolucent areas > 50% of the bone diameter (Neer III) and (D) 12-month follow-up radiograph with remnants of the graft in the proximal region of the cavity (arrow). (E) Twenty-four-month follow-up radiograph showing persistent cystic areas and complete resorption of the bone graft.
Figure 4
Figure 4
Orthogen bone graft block (10 × 20 × 30 mm).
See this image and copyright information in PMC

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