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Review
. 2023 Mar 20;13(3):835.
doi: 10.3390/life13030835.

Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives

Ernesto Punzi  1 , Claudio Carrubba  1 , Andrea Contegiacomo  1 , Alessandro Posa  1 , Pierluigi Barbieri  1 , Davide De Leoni  1 , Giulia Mazza  1 , Alessandro Tanzilli  1 , Alessandro Cina  1 , Luigi Natale  1   2 , Evis Sala  1   2 , Roberto Iezzi  1   2
Affiliations
Review

Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives

Ernesto Punzi et al. Life (Basel). .

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease; patients' long-term survival is strictly linked to the surgical resection of the tumor but only a minority of patients (2-3%) have a resectable disease at diagnosis. In patients with surgically unresectable disease, interventional radiology is taking on an increasing role in treatment with the application of loco-regional percutaneous therapies. The primary purposes of this narrative review are to analyze the safety and efficacy of ablative techniques in the management of borderline resectable and locally advanced diseases and to underline the role of the interventional radiologist in the management of patients with distant metastases. The secondary purpose is to focus on the synergy between immunotherapy and ablative therapies.

Keywords: immunotherapy; irreversible electroporation; liver metastases chemoembolization; pancreatic adenocarcinoma; thermal ablation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
CT scan shows correct placement of the 4 electrodes (19 G) at the periphery of the pancreatic head tumor (interelectrode distance < 20 mm and angulation < 10°).
See this image and copyright information in PMC

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