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Review
. 2023 Mar 6;11(3):671.
doi: 10.3390/microorganisms11030671.

Antibodies to Combat Fungal Infections: Development Strategies and Progress

Ali A Rabaan  1   2   3 , Amal H Alfaraj  4 , Amer Alshengeti  5   6 , Abdulsalam Alawfi  5 , Sara Alwarthan  7 , Mashael Alhajri  7 , Amal H Al-Najjar  8 , Mona A Al Fares  9 , Mustafa A Najim  10 , Souad A Almuthree  11 , Sultan T AlShurbaji  12 , Fadwa S Alofi  13 , Bashayer M AlShehail  14 , Buthina AlYuosof  15 , Ahlam Alynbiawi  16 , Suha A Alzayer  17 , Nawal Al Kaabi  18 , Wesam A Abduljabbar  19 , Zakiyah A Bukhary  20 , Ahmed S Bueid  21
Affiliations
Review

Antibodies to Combat Fungal Infections: Development Strategies and Progress

Ali A Rabaan et al. Microorganisms. .

Abstract

The finding that some mAbs are antifungal suggests that antibody immunity may play a key role in the defense of the host against mycotic infections. The discovery of antibodies that guard against fungi is a significant advancement because it gives rise to the possibility of developing vaccinations that trigger protective antibody immunity. These vaccines might work by inducing antibody opsonins that improve the function of non-specific (such as neutrophils, macrophages, and NK cells) and specific (such as lymphocyte) cell-mediated immunity and stop or aid in eradicating fungus infections. The ability of antibodies to defend against fungi has been demonstrated by using monoclonal antibody technology to reconsider the function of antibody immunity. The next step is to develop vaccines that induce protective antibody immunity and to comprehend the mechanisms through which antibodies mediate protective effects against fungus.

Keywords: NK cells; antibodies; cell-mediated immunity; fungal infections; lymphocyte.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A general mechanism of the Fungal infection and pathogenesis in Humans.
Figure 2
Figure 2
A diagrammatic representation of cellular innate response and humoral response against fungal infections.
See this image and copyright information in PMC

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