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. 2023 Mar 12;11(3):732.
doi: 10.3390/microorganisms11030732.

Clinical Utility of the FilmArray® Blood Culture Identification (BCID) Panel for the Diagnosis of Neonatal Sepsis

María Caunedo-Jiménez  1 , Belén Fernández-Colomer  1 , Jonathan Fernández-Suárez  2 , Rosa Patricia Arias-Llorente  1 , Sonia Lareu-Vidal  1 , Laura Mantecón-Fernández  1 , Gonzalo Solís-Sánchez  1 , Marta Suárez-Rodríguez  1
Affiliations

Clinical Utility of the FilmArray® Blood Culture Identification (BCID) Panel for the Diagnosis of Neonatal Sepsis

María Caunedo-Jiménez et al. Microorganisms. .

Abstract

This prospective single-center study was designed to assess the clinical utility of the FilmArray® blood culture identification (BCID) panel for improving the diagnostic accuracy in neonatal sepsis. Results obtained using the FilmArray® BCID panel were correlated with results of blood culture in all consecutive neonates with suspicion of early-onset (EOS) and late-onset sepsis (LOS) attended in our service over a two-year period. A total of 102 blood cultures from 92 neonates were included, 69 (67.5%) in cases of EOS and 33 (32.3%) in LOS. The FilmArray® BCID panel was performed in negative culture bottles at a median of 10 h of blood culture incubation (IQR 8-20), without differences by the type of sepsis. The FilmArray® BCID panel showed a 66.7% sensitivity, 100% specificity, 100% positive predictive value, and 95.7% negative predictive value. There were four false-negative cases, three of which were Streptococcus epidermidis in neonates with LOS, and there was one case of Granulicatella adiacens in one neonate with EOS. We conclude that the use of the FilmArray® BCID panel in negative blood cultures from neonates with clinical suspicion of sepsis is useful in decision-making of starting or early withdrawal of empirical antimicrobials because of the high specificity and negative predictive values of this assay.

Keywords: FilmArray® blood culture identification panel; blood culture; early-onset sepsis; late-onset sepsis; neonatal sepsis; neonates.

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Conflict of interest statement

The authors declare no conflict of interest. The “Grupo Castrillo” Foundation had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

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