Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar 16;15(6):1427.
doi: 10.3390/nu15061427.

Type 2 Diabetes: Also a "Clock Matter"?

Annamaria Docimo  1 , Ludovica Verde  2 , Luigi Barrea  3 , Claudia Vetrani  3 , Pasqualina Memoli  4 , Giacomo Accardo  5 , Caterina Colella  6 , Gabriella Nosso  7 , Marcello Orio  4 , Andrea Renzullo  7 , Silvia Savastano  1 , Annamaria Colao  1   8 , Giovanna Muscogiuri  1   8
Affiliations

Type 2 Diabetes: Also a "Clock Matter"?

Annamaria Docimo et al. Nutrients. .

Abstract

Background: We investigated whether chronotype is associated with glycemic control, antidiabetic treatment, and risk of developing complications in patients with type 2 diabetes (T2DM).

Methods: The diabetologists filled out an online questionnaire on the Google Form platform to collect the following parameters of subjects with T2DM: body mass index (BMI), fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), diabetes history, antidiabetic treatment, diabetic complications, and chronotype categories.

Results: We enrolled 106 subjects with T2DM (M/F: 58/48; age: 63.3 ± 10.4 years; BMI: 28.8 ± 4.9 kg/m2). Thirty-five point eight% of the subjects showed a morning chronotype (MC), 47.2% an intermediate chronotype (IC), and 17% an evening chronotype (EC). EC subjects reported significantly higher HbA1c (p < 0.001) and FPG (p = 0.004) values, and higher prevalence of cardiovascular complications (CVC) (p = 0.028) and of subjects taking basal (p < 0.001) and rapid insulin (p = 0.01) compared to MC subjects. EC subjects reported significantly higher HbA1c (p < 0.001) and FPG (p = 0.015) than IC subjects. An inverse association was found between chronotype score, HbA1c (r = -0.459; p < 0.001), and FPG (r = -0.269; p = 0.05), remaining significant also after adjustment for BMI, age, and disease duration.

Conclusions: EC is associated with higher prevalence of CVC and poorer glycemic control independently of BMI and disease duration in subjects with T2DM.

Keywords: BMI; HbA1c; chronotype; glycemic control; type 2 diabetes.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Linear correlation between HbA1c and chronotype score.
Figure 2
Figure 2
Linear correlation between fasting blood glucose and chronotype score.
See this image and copyright information in PMC

References

    1. Barrea L., Muscogiuri G., Pugliese G., Modica R., Laudisio D., Aprano S., Faggiano A., Colao A., Savastano S. Chronotype: What role in the context of gastroenteropancreatic neuroendocrine tumors? J. Transl. Med. 2021;19:324. doi: 10.1186/s12967-021-03010-1. - DOI - PMC - PubMed
    1. Barrea L., Vetrani C., Altieri B., Verde L., Savastano S., Colao A., Muscogiuri G. The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus? Nutrients. 2021;13:3762. doi: 10.3390/nu13113762. - DOI - PMC - PubMed
    1. Muscogiuri G., Barrea L., Aprano S., Framondi L., Di Matteo R., Altieri B., Laudisio D., Pugliese G., Savastano S., Colao A. Chronotype and cardio metabolic health in obesity: Does nutrition matter? Int. J. Food Sci. Nutr. 2021;72:892–900. doi: 10.1080/09637486.2021.1885017. - DOI - PubMed
    1. Muscogiuri G., Barrea L., Aprano S., Framondi L., Di Matteo R., Laudisio D., Pugliese G., Savastano S., Colao A., On Behalf Of The Opera Prevention P. Chronotype and Adherence to the Mediterranean Diet in Obesity: Results from the Opera Prevention Project. Nutrients. 2020;12:1354. doi: 10.3390/nu12051354. - DOI - PMC - PubMed
    1. Kivela L., Papadopoulos M.R., Antypa N. Chronotype and Psychiatric Disorders. Curr. Sleep Med. Rep. 2018;4:94–103. doi: 10.1007/s40675-018-0113-8. - DOI - PMC - PubMed