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Review
. 2023 Mar 10;15(3):908.
doi: 10.3390/pharmaceutics15030908.

Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions

Ylenia Della Rocca  1 , Enrico Matteo Traini  1 , Francesca Diomede  1 , Luigia Fonticoli  1 , Oriana Trubiani  1 , Alessia Paganelli  2 , Jacopo Pizzicannella  3 , Guya Diletta Marconi  1
Affiliations
Review

Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions

Ylenia Della Rocca et al. Pharmaceutics. .

Abstract

Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. The purpose of this review is to analyze the mechanism of action of bisphenol A, with a special focus on mesenchymal stromal/stem cells (MSCs) and adipogenesis. Its uses will be assessed in various fields: dental, orthopedic, and industrial. The different pathological or physiological conditions altered by BPA and the related molecular pathways will be taken into consideration.

Keywords: bisphenol A; endocrine disruptors; mesenchymal stem cells.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Potential BPA origin. BPA exposure sources involve ingestion, maternofetal transmission, inhalation, skin, and eye contact. (Created with BioRender.com).
Figure 2
Figure 2
The adverse effects of bisphenol A on human health. BPA can negatively impact different targets once introduced into the human body, such as thyroid, heart, reproductive apparatus, gut, immune system, and kidneys (created with BioRender.com).
Figure 3
Figure 3
Schematic representation of the main targets for BPA in the human body, including MSCs (mesenchymal stem cells). Created with BioRender.com.
See this image and copyright information in PMC

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